Plant Extracts and Phytochemicals, a Promising Strategy Against Oral Lichen Planus: A Review on Clinical Trials

被引：3
作者：
Gupta S. [1 ]
Nath L.R. [1 ]
Mangalathillam S. [1 ]
机构：
[1] Department of Pharmaceutics, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Ponekkara P.O, Kerala, Kochi
来源：
Recent Patents on Biotechnology | 2023年 / 17卷 / 01期
关键词：
autoimmune; clinical trials; COVID-19; INF-γ; Oral lichen planus; phytochemicals;
D O I：
10.2174/1872208316666220718145421
中图分类号：
学科分类号：
摘要：
Background: Oral lichen planus (OLP) is an autoimmune disease that distress keratinized cells of the oral epithelium. Topical corticosteroids and other potential thera-pies like immunosuppressives, hydroxychloroquine, azathioprine, mycophenolate, dap-sone, retinoids, biologic agents are used for the management of OLP. However, their effec-tiveness, best dose, duration of treatment and safety remain mostly unidentified. Moreover, recurrence of disease and dose-related side effects are the other issues. Objective: The primary objective of the review is to explore the existing clinical trials for the efficacy of phytochemicals in treating OLP in comparison to corticosteroids. A com-prehensive information about their mode of action is also discussed. Methods: We have discussed different clinical trials conducted on various phytochemicals and plant extracts/formulations like curcumin, lycopene, quercetin, glycyrrhizin, purslane, raspberry, aloe vera gel and aloe vera mouthwash for the treatment of OLP. Results: The current therapy for the management of OLP has numerous adverse effects and requires a long-term treatment. Phytochemicals can be a very good alternative in overcom-ing these side effects and reducing the course of treatment. Conclusion: Herbal extracts and their formulations can be an effective alternative to the current therapy due to their proven therapeutic effects, reduced side effects, long-term ap-plicability, prevention of recurrence as well as progression into cancer. © 2023 Bentham Science Publishers.
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页码：80 / 91
页数：11
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