Plant Extracts and Phytochemicals, a Promising Strategy Against Oral Lichen Planus: A Review on Clinical Trials

被引：3
作者：
Gupta S. [1 ]
Nath L.R. [1 ]
Mangalathillam S. [1 ]
机构：
[1] Department of Pharmaceutics, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Ponekkara P.O, Kerala, Kochi
来源：
Recent Patents on Biotechnology | 2023年 / 17卷 / 01期
关键词：
autoimmune; clinical trials; COVID-19; INF-γ; Oral lichen planus; phytochemicals;
D O I：
10.2174/1872208316666220718145421
中图分类号：
学科分类号：
摘要：
Background: Oral lichen planus (OLP) is an autoimmune disease that distress keratinized cells of the oral epithelium. Topical corticosteroids and other potential thera-pies like immunosuppressives, hydroxychloroquine, azathioprine, mycophenolate, dap-sone, retinoids, biologic agents are used for the management of OLP. However, their effec-tiveness, best dose, duration of treatment and safety remain mostly unidentified. Moreover, recurrence of disease and dose-related side effects are the other issues. Objective: The primary objective of the review is to explore the existing clinical trials for the efficacy of phytochemicals in treating OLP in comparison to corticosteroids. A com-prehensive information about their mode of action is also discussed. Methods: We have discussed different clinical trials conducted on various phytochemicals and plant extracts/formulations like curcumin, lycopene, quercetin, glycyrrhizin, purslane, raspberry, aloe vera gel and aloe vera mouthwash for the treatment of OLP. Results: The current therapy for the management of OLP has numerous adverse effects and requires a long-term treatment. Phytochemicals can be a very good alternative in overcom-ing these side effects and reducing the course of treatment. Conclusion: Herbal extracts and their formulations can be an effective alternative to the current therapy due to their proven therapeutic effects, reduced side effects, long-term ap-plicability, prevention of recurrence as well as progression into cancer. © 2023 Bentham Science Publishers.
引用
收藏
页码：80 / 91
页数：11
相关论文
共 87 条
  • [1] Canto AM, Muller H, Freitas RR, Santos PS., Oral lichen planus (OLP): Clinical and complementary di-agnosis, An Bras Dermatol, 85, 5, pp. 669-675, (2010)
  • [2] Sugerman PB, Savage NW, Walsh LJ, Et al., The pathogenesis of oral lichen planus, Crit Rev Oral Biol Med, 13, 4, pp. 350-365, (2002)
  • [3] Alrashdan MS, Cirillo N, McCullough M., Oral lichen planus: A literature review and update, Arch Dermatol Res, 308, 8, pp. 539-551, (2016)
  • [4] Nogueira PA, Carneiro S, Ramos-e-Silva M., Oral lichen planus: An update on its pathogenesis, Int J Dermatol, 54, 9, pp. 1005-1010, (2015)
  • [5] Eisen D, Ellis CN, Duell EA, Griffiths CE, Voorhees JJ., Effect of topical cyclosporine rinse on oral lichen planus. A double-blind analysis, N Engl J Med, 323, 5, pp. 290-294, (1990)
  • [6] Chainani-Wu N, Collins K, Silverman S, Use of curcuminoids in a cohort of patients with oral lichen planus, an autoimmune disease, Phytomedicine, 19, 5, pp. 418-423, (2012)
  • [7] Airas L., Hormonal and gender-related immune changes in multiple sclerosis, Acta Neurol Scand, 132, 199, pp. 62-70, (2015)
  • [8] Zhang MA, Rego D, Moshkova M, Et al., Peroxisome proliferator-activated receptor (PPAR) α and-γ regu-late IFNγ and IL-17A production by human T cells in a sex-specific way, Proc Natl Acad Sci USA, 109, 24, pp. 9505-9510, (2012)
  • [9] Voskuhl RR, Gold SM., Sex-related factors in multiple sclerosis susceptibility and progression, Nat Rev Neurol, 8, 5, pp. 255-263, (2012)
  • [10] Antulov R, Weinstock-Guttman B, Cox JL, Et al., Gender-related differences in MS: A study of conven-tional and nonconventional MRI measures, Mult Scler, 15, 3, pp. 345-354, (2009)
123456789