Impacts of PFOS, PFOA and their alternatives on the gut, intestinal barriers and gut-organ axis

被引：0
作者：
Zhang B. [1 ]
Yang Y. [1 ]
Li Q. [1 ]
Ding X. [1 ]
Tian M. [1 ]
Ma Q. [1 ]
Xu D. [1 ]
机构：
[1] Institute of Environmental Systems Biology, Environment Science and Engineering College, Dalian Maritime University, Linghai Road 1, Dalian
来源：
Chemosphere | 2024年 / 361卷
基金：
中国国家自然科学基金;
关键词：
Alternatives; Gut-organ axis; Intestinal barrier; PFOA; PFOS;
D O I：
10.1016/j.chemosphere.2024.142461
中图分类号：
学科分类号：
摘要：
With the restricted use of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), a number of alternatives to PFOS and PFOA have attracted great interest. Most of the alternatives are still characterized by persistence, bioaccumulation, and a variety of toxicity. Due to the production and use of these substances, they can be detected in the atmosphere, soil and water body. They affect human health through several exposure pathways and especially enter the gut by drinking water and eating food, which results in gut toxicity. In this review, we summarized the effects of PFOS, PFOA and 9 alternatives on pathological changes in the gut, the disruption of physical, chemical, biological and immune barriers of the intestine, and the gut-organ axis. This review provides a valuable understanding of the gut toxicity of PFOS, PFOA and their alternatives as well as the human health risks of emerging contaminants. © 2024 Elsevier Ltd
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