Continuous flow synthesis of nitrochlorobenzene in microtubular reactor

被引：0

作者：

Zhang X. ^{[1
]}

Shang Z. ^{[1
]}

Zhang X. ^{[1
]}

机构：

[1] School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Hebei, Shijiazhuang

来源：

Huagong Jinzhan/Chemical Industry and Engineering Progress | 2022年 / 41卷 / 09期

关键词：

chlorobenzene nitration; continuous flow; microtubular reactor; nitrochlorobenzene;

D O I：

10.16085/j.issn.1000-6613.2021-2284

中图分类号：

学科分类号：

摘要：

The nitration of aromatic compounds is a rapid and strong exothermic reaction, and continuous process can reduce the potential risk caused by batch operations. The continuous nitration of chlorobenzene was carried out in a 10mL microtubular reactor on basis of the flow condition study by the visualization method and computational fluid dynamics (CFD) simulation. Some effects on the reaction conversion, yield, o-/p-nitrochlorobenzene ratio and selectivity were investigated, such as the residence time, temperature, mixed acid ratio (the molar ratio of nitric acid to sulfuric acid) and phase ratio (the molar ratio of nitric acid to chlorobenzene). The results showed that the chlorobenzene and mixed acid phases in a microchannel with an inner diameter of 1mm exhibited the Taylor flow pattern, which can enhance the efficiency of mass and heat transfer, leading to increase the macro reaction rate. When the residence time was 8min, the temperature was 80℃, the mixed acid ratio was 1 : 1.5 and the molar ratio of nitric acid to chlorobenzene was 1 : 1, the ratio of o-/p-nitrochlorobenzene was between 0.7—0.8, the single-pass conversion of chlorobenzene was 81.24% and the selectivity of mononitrochlorobenzene was 93.77%. The continuous nitrification can greatly shorten the residence time and significantly improve the o-/p-nitrochlorobenzene ratio. Compared with conventional kettle process, the continuous nitration of chlorobenzene in microtubular reactor was safer and more efficient. © 2022 Chemical Industry Press. All rights reserved.

引用

页码：5022 / 5028

页数：6

共 17 条

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