Macrophage-targeted mannose-decorated PLGA-vegetable oil hybrid nanoparticles loaded with anti-inflammatory agents

被引：0
|
作者：
Ghitman, Jana [1 ]
Pircalabioru, Gratiela Gradisteanu [2 ,3 ]
Zainea, Adriana [1 ]
Marutescu, Luminita [2 ,3 ]
Iovu, Horia [1 ,4 ]
Vasile, Eugeniu [5 ]
Stavarache, Cristina [1 ]
Vasile, Bogdan Stefan [6 ]
Stan, Raluca [7 ]
机构：
[1] Advanced Polymer Materials Group, University Politehnica of Bucharest, 1–7 Gh Polizu Street, Bucharest,011061, Romania
[2] Microbiology Immunology Department, Faculty of Biology, University of Bucharest, Bucharest,050095, Romania
[3] Research Institute of the University of Bucharest, Bucharest,050095, Romania
[4] Academy of Romanian Scientists, 54 Splaiul Independentei Street, Bucharest,050094, Romania
[5] Department of Oxide Materials Science and Engineering, University Politehnica of Bucharest, 1–7 Gh. Polizu Street, Bucharest,011061, Romania
[6] National Research Center for Micro and Nanomaterials, National Research Center for Food Safety, University Politehnica of Bucharest, Bucharest,060042, Romania
[7] Department of Organic Chemistry C. Nenitzescu, University Politehnica of Bucharest, 1–7 Gh Polizu Street, Bucharest,011061, Romania
来源：
Colloids and Surfaces B: Biointerfaces | 2022年 / 213卷
关键词：
Emulsions - Vegetable oils - Nanoparticles - Targeted drug delivery - Controlled drug delivery - Efficiency - Emulsification - Biocompatibility;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This work pledge to extend the therapeutic windows of hybrid nanoparticulate systems by engineering mannose-decorated hybrid nanoparticles based on poly lactic-co-glycolic acid (PLGA) and vegetable oil for efficient delivery of two lipophilic anti-inflammatory therapeutics (Celecoxib-CL and Indomethacin-IMC) to macrophages. The mannose surface modification of nanoparticles is achieved via O-palmitoyl-mannose spacer during the emulsification and nanoparticles assembly process. The impact of targeting motif on the hydrodynamic features (RH, PdI), stability (ζ-potential), drug encapsulation efficiency (DEE) is thoroughly investigated. Besides, the in vitro biocompatibility (MTT, LDH) and susceptibility of mannose-decorated formulations to macrophage as well their immunomodulatory activity (ELISA) are also evaluated. The monomodal distributed mannose-decorated nanoparticles are in the range of nanometric size (RH © 2022 Elsevier B.V.
引用
收藏
相关论文
共 30 条
  • [11] Studying the Effect of PMG on the Hydrodynamic Characteristics and Stability of PLGA-Vegetable Oil Hybrid Nanoparticles Obtained by Emulsion Solvent Evaporation Method
    Ghitman, Jana
    Stan, Raluca L.
    MATERIALE PLASTICE, 2019, 56 (04) : 857 - 864
  • [12] Anti-obesity and anti-inflammatory effects of macrophage-targeted interleukin-10-conjugated liposomes in obese mice
    Toita, Riki
    Kawano, Takahito
    Murata, Masaharu
    Kang, Jeong-Hun
    BIOMATERIALS, 2016, 110 : 81 - 88
  • [13] Ramulus mori polysaccharide-loaded PLGA nanoparticles and their anti-inflammatory effects in vivo
    Feng, Zian
    Peng, Song
    Wu, Zhiyong
    Jiao, Lina
    Xu, Shuwen
    Wu, Yu
    Liu, Zhenguang
    Hu, Yuanliang
    Liu, Jiaguo
    Wu, Yi
    Wang, Deyun
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, 182 : 2024 - 2036
  • [14] PEG-Lipid-PLGA Hybrid Particles for Targeted Delivery of Anti-Inflammatory Drugs
    Ismail, Jana
    Klepsch, Lea C.
    Dahlke, Philipp
    Tsarenko, Ekaterina
    Vollrath, Antje
    Pretzel, David
    Jordan, Paul M.
    Rezaei, Kourosh
    Czaplewska, Justyna A.
    Stumpf, Steffi
    Beringer-Siemers, Baerbel
    Nischang, Ivo
    Hoeppener, Stephanie
    Werz, Oliver
    Schubert, Ulrich S.
    PHARMACEUTICS, 2024, 16 (02)
  • [15] Harnessing β-glucan conjugated quercetin nanocomplex to function as a promising anti-inflammatory agent via macrophage-targeted delivery
    Su, Yuting
    Huang, Manting
    Chen, Qiaochun
    He, Jiayi
    Li, Siqian
    Wang, Mingfu
    CARBOHYDRATE POLYMERS, 2025, 349
  • [16] Targeted Delivery of Anti-inflammatory and Imaging Agents to Microglial Cells with Polymeric Nanoparticles
    Cahalane, Celina
    Bonezzi, Jason
    Shelestak, John
    Clements, Robert
    Boika, Aliaksei
    Yun, Yang H.
    Shriver, Leah P.
    MOLECULAR PHARMACEUTICS, 2020, 17 (06) : 1816 - 1826
  • [17] Cholesterol-functionalized carvedilol-loaded PLGA nanoparticles: anti-inflammatory, antioxidant, and antitumor effects
    de Oliveira, Ana Luiza C. S. L.
    dos Santos-Silva, Alaine M.
    da Silva-Junior, Arnobio A.
    Garcia, Vinicius B.
    de Araujo, Aurigena A.
    de Geus-Oei, Lioe-Fee
    Chan, Alan B.
    Cruz, Luis J.
    de Araujo Junior, Raimundo F.
    JOURNAL OF NANOPARTICLE RESEARCH, 2020, 22 (05)
  • [18] Cholesterol-functionalized carvedilol-loaded PLGA nanoparticles: anti-inflammatory, antioxidant, and antitumor effects
    Ana Luiza C. de S. L. Oliveira
    Alaine M. dos Santos-Silva
    Arnóbio A. da Silva-Júnior
    Vinícius B. Garcia
    Aurigena A. de Araújo
    Lioe-Fee de Geus-Oei
    Alan B. Chan
    Luis J. Cruz
    Raimundo F. de Araújo Júnior
    Journal of Nanoparticle Research, 2020, 22
  • [19] Dry Powder Comprised of Isoniazid-Loaded Nanoparticles of Hyaluronic Acid in Conjugation with Mannose-Anchored Chitosan for Macrophage-Targeted Pulmonary Administration in Tuberculosis
    Mukhtar, Mahwash
    Csaba, Noemi
    Robla, Sandra
    Varela-Calvino, Ruben
    Nagy, Attila
    Burian, Katalin
    Kokai, David
    Ambrus, Rita
    PHARMACEUTICS, 2022, 14 (08)
  • [20] Biocompatibility, anti-inflammatory, wound healing, and antifungal activity of macrophage targeted-bacterioruberin-vitamin D3 loaded nanoparticles
    Simioni, Yamila Roxana
    Usseglio, Nadina
    Butassi, Estefania
    Altube, Maria Julia
    Higa, Leticia Herminia
    Romero, Eder Lilia
    Schilrreff, Priscila
    Morilla, Maria Jose
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2025, 105
123