Macrophage-targeted mannose-decorated PLGA-vegetable oil hybrid nanoparticles loaded with anti-inflammatory agents

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作者：
Ghitman, Jana [1 ]
Pircalabioru, Gratiela Gradisteanu [2 ,3 ]
Zainea, Adriana [1 ]
Marutescu, Luminita [2 ,3 ]
Iovu, Horia [1 ,4 ]
Vasile, Eugeniu [5 ]
Stavarache, Cristina [1 ]
Vasile, Bogdan Stefan [6 ]
Stan, Raluca [7 ]
机构：
[1] Advanced Polymer Materials Group, University Politehnica of Bucharest, 1–7 Gh Polizu Street, Bucharest,011061, Romania
[2] Microbiology Immunology Department, Faculty of Biology, University of Bucharest, Bucharest,050095, Romania
[3] Research Institute of the University of Bucharest, Bucharest,050095, Romania
[4] Academy of Romanian Scientists, 54 Splaiul Independentei Street, Bucharest,050094, Romania
[5] Department of Oxide Materials Science and Engineering, University Politehnica of Bucharest, 1–7 Gh. Polizu Street, Bucharest,011061, Romania
[6] National Research Center for Micro and Nanomaterials, National Research Center for Food Safety, University Politehnica of Bucharest, Bucharest,060042, Romania
[7] Department of Organic Chemistry C. Nenitzescu, University Politehnica of Bucharest, 1–7 Gh Polizu Street, Bucharest,011061, Romania
来源：
Colloids and Surfaces B: Biointerfaces | 2022年 / 213卷
关键词：
Emulsions - Vegetable oils - Nanoparticles - Targeted drug delivery - Controlled drug delivery - Efficiency - Emulsification - Biocompatibility;
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摘要：
This work pledge to extend the therapeutic windows of hybrid nanoparticulate systems by engineering mannose-decorated hybrid nanoparticles based on poly lactic-co-glycolic acid (PLGA) and vegetable oil for efficient delivery of two lipophilic anti-inflammatory therapeutics (Celecoxib-CL and Indomethacin-IMC) to macrophages. The mannose surface modification of nanoparticles is achieved via O-palmitoyl-mannose spacer during the emulsification and nanoparticles assembly process. The impact of targeting motif on the hydrodynamic features (RH, PdI), stability (ζ-potential), drug encapsulation efficiency (DEE) is thoroughly investigated. Besides, the in vitro biocompatibility (MTT, LDH) and susceptibility of mannose-decorated formulations to macrophage as well their immunomodulatory activity (ELISA) are also evaluated. The monomodal distributed mannose-decorated nanoparticles are in the range of nanometric size (RH © 2022 Elsevier B.V.
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