Composition Analysis, Anticancer and Immune Activities of Polysaccharides from Poria cocos Residues in Vitro

被引：0

作者：

Guan Y. ^{[1
,2
]}

Wen S. ^{[1
,2
]}

Feng X. ^{[3
]}

Bai Y. ^{[3
]}

Chen R. ^{[1
,2
]}

Shen X. ^{[1
,2
]}

Feng J. ^{[1
,2
]}

Chang S. ^{[1
,2
]}

Cheng X. ^{[3
]}

机构：

[1] College of Life Sciences and Food Engineering, Hebei University of Engineering, Handan

[2] Handan Key Laboratory of Natural Products and Functional Foods, Handan

[3] Chenguang Biotech Group Co., Ltd., Handan

来源：

Science and Technology of Food Industry | 2022年 / 43卷 / 21期

关键词：

antitumor activity; immune activity; polysaccharide; Poria cocos; structural characterization;

D O I：

10.13386/j.issn1002-0306.2022010168

中图分类号：

学科分类号：

摘要：

Objective: The monosaccharide composition of Poria cocos polysaccharide (PCOS) from Poria cocos residue extracted by hot water, as well as its anti-cancer, anti-inflammatory factors and immune activities were studied, providing a theoretical foundation for the development of PCOS related products. Methods: The monosaccharide composition of water-extracted PCOS was analyzed by HPLC and FTIR, and the anti-tumor and immune activities of water-extracted PCOS were studied by CCK-8 method. Results: The polysaccharide content of PCOS was 76%, mainly composed of glucose, mannose, galactose and fucose, and the molar ratio was 1:0.107:0.079:0.018, with obvious polysaccharide characteristic absorption peak. The proliferation of gastric cancer cells, breast cancer cells, and liver cancer cells was decreased, with the best inhibition impact on gastric cancer cells (IC50=1096 μg/mL), and spleen lymphocyte proliferation in mice was enhanced. Conclusion: The water-extracted PCOS has good anti-cancer and immune activities in vitro. © The Author(s) 2022.

引用

页码：381 / 387

页数：6

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