Human dentin coated with silver nanoclusters exhibits antibacterial activity against streptococcus mutans

被引：0

作者：

Shitomi K. ^{[2
]}

Miyaji H. ^{[2
]}

Miyata S. ^{[2
]}

Nishida E. ^{[2
]}

Mayumi K. ^{[2
]}

Sugaya T. ^{[2
]}

Kawasaki H. ^{[1
]}

机构：

[1] Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka

[2] Department of Periodontology and Endodontology, Faculty of Dental Medicine, Hokkaido University, N13 W7, Kita-ku, Sapporo

来源：

Nano Biomedicine | 2019年 / 11卷 / 01期

基金：

日本学术振兴会;

关键词：

Antibacterial effect; Human dentin; Silver nanoclusters (AgNCs); Streptococcus mutans;

D O I：

10.11344/nano.11.21

中图分类号：

学科分类号：

摘要：

Silver nanoclusters (AgNCs) are ultrasmall in size (< 2 nm) and are expected to be an effective antibacterial substance to combat oral infective diseases. In the present study, we synthesized AgNCs (Ag~75) as the main component for esthetic and antibacterial application against the caries pathogen Streptococcus mutans. The results showed that AgNCs significantly reduced the turbidity and viability of S. mutans. In addition, the bactericidal effects of AgNCs were confirmed by LIVE/DEAD staining. After AgNC application to human dentin, no discoloration of dentin was observed, as compared to silver diamine fluoride application, and AgNC-treated dentin showed an inhibitory effect on colony formation by S. mutans. Therefore, AgNCs appear to be beneficial for dental therapy as an antibacterial and/or esthetic substrate. © 2019 National Institute of Informatics. All rights reserved.

引用

页码：21 / 28

页数：7

共 22 条

[1]

Loesche W.J., Role of Streptococcus mutans in human dental decay, Microbiol Rev, 50, pp. 353-380, (1986)

[2]

Fitzgerald R.J., Dental caries research in gnoto-biotic animals, Caries Res, 2, pp. 139-146, (1968)

[3]

Keyes P.H., Jordan H.V., Periodontal lesions in the hamster. III. Findings related to an infectious and transmissible component, Arch Oral Biol, 9, pp. 377-400, (1964)

[4]

Corbin A., Pitts B., Parker A., Stewart P.S., Antimicrobial penetration and efficacy in an in vitro oral biofilm model, Antimicrob Agents Chemother, 55, pp. 3338-3344, (2011)

[5]

Tominaga C., Shitomi K., Miyaji H., Kawasaki H., Antibacterial photocurable acrylic resin coating using a conjugate between silver nanoclusters and alkyl quaternary ammonium, ACS Appl. Nano Mater., 1, pp. 4809-4818, (2018)

[6]

Amiri M., Etemadifar Z., Daneshkazemi A., Nateghi M., Antimicrobial effect of copper oxide nanoparticles on some oral bacteria and candida species, J Dent Biomater, 4, pp. 347-352, (2017)

[7]

Almoudi M.M., Hussein A.S., Hassan M.I.A., Zainc N.M., A systematic review on antibacterial activity of zinc against Streptococcus mutans, Saudi Dent J, 30, pp. 283-291, (2018)

[8]

Feng Q.L., Wu J., Chen G.Q., Cui F.Z., Kim T.N., Kim J.O., A mechanistic study of the antibacterial effect of silver ions on Escherichia coli and Staphylococcus aureus, J Biomed Mater, 2, pp. 662-668, (2000)

[9]

Duangthip D., Chu C.H., Lo E.C., A randomized clinical trial on arresting dentine caries in preschool children by topical fluorides-18 month results, J Dent, 44, pp. 57-63, (2016)

[10]

Patel J., Anthonappa R.P., King N.M., Evaluation of the staining potential of silver diamine fluoride: In vitro, Int J Paediatr Dent, 28, pp. 514-522, (2018)

← 1 2 3 →