Elastic 3D-Printed Nanofibers Composite Scaffold for Bone Tissue Engineering

被引：0

作者：

Cai P. ^{[1
]}

Li C. ^{[2
]}

Ding Y. ^{[1
]}

Lu H. ^{[1
]}

Yu X. ^{[1
]}

Cui J. ^{[1
]}

Yu F. ^{[1
]}

Wang H. ^{[1
]}

Wu J. ^{[1
]}

EL-Newehy M. ^{[3
]}

Abdulhameed M.M. ^{[3
]}

Song L. ^{[2
]}

Mo X. ^{[1
]}

Sun B. ^{[1
]}

机构：

[1] Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine & College of Biological Science and Medical Engineering, Donghua University, Shanghai

[2] Department of Stomatology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai

[3] Department of Chemistry, College of Science, King Saud University, Riyadh

来源：

ACS Applied Materials and Interfaces | 2023年 / 15卷 / 47期

关键词：

3D printing; bone regeneration; nanofibers; scaffold; tissue engineering;

D O I：

10.1021/ACSAMI.3C12426

中图分类号：

学科分类号：

摘要：

Loading nanoparticles into hydrogels has been a conventional approach to augment the printability of ink and the physicochemical characteristics of scaffolds in three-dimensional (3D) printing. However, the efficacy of this enhancement has often proven to be limited. We amalgamate electrospun nanofibers with 3D printing techniques to fabricate a composite scaffold reminiscent of a “reinforced concrete” structure, aimed at addressing bone defects. These supple silica nanofibers are synthesized through a dual-step process involving high-speed homogenization and low-temperature ball milling technology. The nanofibers are homogeneously blended with sodium alginate to create the printing ink. The resultant ink was extruded seamlessly, displaying commendable molding properties, thereby yielding scaffolds with favorable macroscopic morphology. In contrast to nanoparticle-reinforced scaffolds, composite scaffolds containing nanofibers exhibit superior mechanical attributes and bioactivity. These nanofiber composite scaffolds demonstrate enhanced osteoinductive properties in both in vitro and in vivo evaluations. To conclude, this research introduces a novel 3D printing approach where the fabricated nanofiber-infused 3D-printed scaffolds hold the potential to revolutionize the realm of 3D printing in the domain of bone tissue engineering. © 2023 American Chemical Society.

引用

页码：54280 / 54293

页数：13