Characterizing the mechanical variations of human femoropopliteal artery during aging process

被引：0

作者：

Yang S. ^{[1
]}

Qi Y. ^{[2
]}

Jiang Z. ^{[2
]}

Gong X. ^{[1
]}

机构：

[1] Key Laboratory of Hydrodynamics (Ministry of Education), Department of Engineering Mechanics, School of Naval Architecture, Ocean and Civil Engineering, Shanghai Jiao Tong University, Shanghai

[2] Institute of Mechanobiology and Biomedical Engineering, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai

来源：

MCB Molecular and Cellular Biomechanics | 2019年 / 16卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Aging; Femoropopliteal artery; Mechanical stress and strain; Vascular mechanobiology; Wall stiffness;

D O I：

10.32604/mcb.2019.06096

中图分类号：

学科分类号：

摘要：

Vascular diseases during aging process are closely correlated to the age-related changes of mechanical stimuli for resident cells. Characterizing the variations of mechanical environments in vessel walls with advancing age is crucial for a better understanding of vascular remodeling and pathological changes. In this study, the mechanical stress, strain, and wall stiffness of the femoropopliteal arteries (FPAs) were compared among four different age groups from adolescent to young, middle-aged, and aged subjects. The material parameters and geometries adopted in the FPA models were obtained from published experimental results. It is found that high mechanical stress appears at different layers in young and old FPA walls respectively. The characteristics of the middle-aged FPA wall suggests that it is the most capable of resisting high blood pressures and maintaining a mechanical homeostasis during the entire life span. It is demonstrated that the variations of stress and strain rather than that of wall stiffness can be used as an indicator to illustrate the profile of FPA aging. Our results could serve as an age-specific mechanical reference for vascular mechanobiological studies, and allow further exploration of cellular dysfunctions in vessel walls during aging process. Copyright © 2019 Tech Science Press

引用

页码：13 / 26

页数：13

共 26 条

[1]

Boileau E., Nithiarasu P., Blanco P.J., Muller L.O., Fossan F.E., Et al., A benchmark study of numerical schemes for one-dimensional arterial blood flow modelling, International Journal for Numerical Methods in Biomedical Engineering, 31, 10, pp. 1-33, (2015)

[2]

Bortolotto L.A., Hanon O., Franconi G., Boutouyrie P., Legrain S., Et al., The aging process modifies the distensibility of elastic but not muscular arteries, Hypertension, 34, pp. 889-892, (1999)

[3]

Cattaruzza M., Dimigen C., Ehrenreich H., Hecker M., Stretch-induced endothelin B receptor-mediated apoptosis in vascular smooth muscle cells, FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 14, 7, pp. 991-998, (2000)

[4]

Chuong C.J., Fung Y.C., Three-dimensional stress distribution in arteries, Journal of Biomechanical Engineering, 105, 3, pp. 268-274, (1983)

[5]

Desyatova A., MacTaggart J., Kamenskiy A., Constitutive modeling of human femoropopliteal artery biaxial stiffening due to aging and diabetes, Acta Biomaterialia, 64, pp. 50-58, (2017)

[6]

Desyatova A., MacTaggart J., Romarowski R., Poulson W., Conti M., Et al., Effect of aging on mechanical stresses, deformations, and hemodynamics in human femoropopliteal artery due to limb flexion, Biomechanics and Modeling in Mechanobiology, 17, 1, pp. 181-189, (2018)

[7]

Fung Y.C., What are the residual stresses doing in our blood vessels?, Annals of Biomedical Engineering, 19, 3, pp. 237-249, (1991)

[8]

Gosling R.G., Budge M.M., Terminology for describing the elastic behavior of arteries, Hypertension, 41, 6, pp. 1180-1182, (2003)

[9]

Han H.C., Fung Y.C., Direct measurement of transverse residual strains in aorta, The American Journal of Physiology, 270, pp. 750-759, (1996)

[10]

Hayashi K., Sugawara J., Komine H., Maeda S., Yokoi T., Effects of aerobic exercise training on the stiffness of central and peripheral arteries in middle-aged sedentary men, Japanese Journal of Physiology, 55, 4, pp. 235-239, (2005)

← 1 2 3 →