An Overview of Pharmacological Activities and Beneficial Effects of 3-Hydroxyflavone

Flavonoids are a diverse group of naturally occurring plant compounds that are primarily composed of phenols in their free form or glycosides. Flavonoid medicines are primarily composed of 2-phenyl-g-benzopyrone. This family consists of monomeric flavanols, flavanones, anthocyanidins, flavones, isoflavonoids, and flavonols. The study's main objective is to review the newly discovered natural flavones and flavanols, as well as the biological and pharmacological actions of these essential flavonoids. As per the available data, 3-hydroxy flavone plays a vital role in the prevention of a range of diseases. Research studies have confirmed that 3-hydroxyflavone has a broad range of pharmacological properties like therapeutic effects against pain, inflammation, oxidative stress; hepatotoxicity, hypertension, ulcerogenesis, allergy, platelet dysfunction, microbes, fungi, viruses, rhinovirus, malaria, and carcinogens. 3-Hydroxy flavone has limited utility because of their poor solubility and bioavailability. This has led to the search for new drug delivery methods, such as nanoparticles. To get over these problems, it would be preferable to administer 3-hydroxyflavone via the biocompatible nanoparticles. It is expected that nanoparticles will improve the solubility of 3-hydroxyflavone, enhance its therapeutic properties and facilitate its transport to the brain. © 2024 Wiley-VCH GmbH.