Additive manufacture of PCL/nHA scaffolds reinforced with biodegradable continuous Fibers: Mechanical Properties, in-vitro degradation Profile, and cell study

被引：0

作者：

Hedayati, Seyyed Kaveh ^{[1
]}

Behravesh, Amir Hossein ^{[1
]}

Hasannia, Sadegh ^{[2
,3
]}

Kordi, Omid ^{[1
]}

Pourghaumi, Majid ^{[1
]}

Saed, Arvin Bagheri ^{[1
]}

Gashtasbi, Fatemeh ^{[3
]}

机构：

[1] Additive Manufacturing Laboratory, Faculty of Mechanical Engineering, Tarbiat Modares University, Tehran, Iran

[2] Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran

[3] Nova Teb Research Laboratory, Dental Equipment and Bio-material Technology Incubation Center, Tehran, Iran

来源：

European Polymer Journal | 2022年 / 162卷

关键词：

In this study; an innovative method of in-situ impregnation was implemented in the Fused Deposition Modeling (FDM) process to produce poly (∊‐caprolactone) (PCL) scaffolds with enhanced mechanical and biological properties utilizing continuous biodegradable polyglycolic acid (PGA) suture yarns. The study aimed to introduce composite scaffolds; having a nominal porosity of 60% and 0°/60°/120° fibers layout; with tunable mechanical and biological properties for tissue engineering applications. Three different fiber volume contents (15; 25; and 35 vol%) were successfully embedded in the specimens during printing. To enhance the compressive properties; nano‐hydroxyapatite (nHA) was added to the PCL matrix in three levels (0; 10; and 20 wt%). Degradation behaviors of both tensile and compression specimens were also assessed in DMEM and Sörensen buffer. The biological properties of the scaffolds; including surface morphology; biocompatibility; and cell adhesion; were also evaluated. According to the results; incorporating the PGA fibers and nHA particles remarkably enhanced mechanical properties; degradation; and cell adhesion. Also; the composite scaffolds exhibited superior water uptake and hydrophilicity compared to the non-reinforced ones. The results suggest that the introduced 3D printed composite can be produced as a suitable material for bone tissue engineering and resorbable barrier membrane with the desired properties. © 2021 Elsevier Ltd;

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共 3 条

[1] 3D printed PCL scaffold reinforced with continuous biodegradable fiber yarn: A study on mechanical and cell viability properties
Hedayati, Seyyed Kaveh
Behravesh, Amir Hossein
Hasannia, Sadegh
Saed, Arvin Bagheri
Akhoundi, Behnam
POLYMER TESTING, 2020, 83 (83)
[2] Mechanical study of PLA-PCL fibers during in vitro degradation
Vieira, A. C.
Vieira, J. C.
Ferra, J. M.
Magalhaes, F. D.
Guedes, R. M.
Marques, A. T.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 2011, 4 (03) : 451 - 460
[3] In vitro degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerization
Felfel, R. M.
Poocza, Leander
Gimeno-Fabra, Miquel
Milde, Tobias
Hildebrand, Gerhard
Ahmed, Ifty
Scotchford, Colin
Sottile, Virginie
Grant, David M.
Liefeith, Klaus
BIOMEDICAL MATERIALS, 2016, 11 (01)

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