Antiviral activity of sulfated polysaccharides from marine algae and its application in combating COVID-19: Mini review

被引：112
作者：
Hans N. [1 ]
Malik A. [1 ]
Naik S. [1 ]
机构：
[1] Centre for Rural Development and Technology, Indian Institute of Technology Delhi, New Delhi
来源：
Bioresource Technology Reports | 2021年 / 13卷
关键词：
Drug development; Immune response; Respiratory syndrome; Structural classification; Sulfated galactans; Virucidal activity;
D O I：
10.1016/j.biteb.2020.100623
中图分类号：
学科分类号：
摘要：
Marine-derived sulfated polysaccharides possess various antiviral activities against a broad range of enveloped and non-enveloped viruses. It has become the potential source of antiviral drugs for pharmaceutical development. In this review, we will discuss the different types of sulfated polysaccharides and their structural classification. Some of the major sulfated polysaccharides with potent antiviral activity, including carrageenan, agar, ulvan, fucoidan, and alginates, are considered in this review. The mechanism of these sulfated polysaccharides in inhibiting the different stages of the viral infection process inside the host cell is also demonstrated. It involves blocking the initial entry of the virus or inhibiting its transcription and translation by modulating the immune response of the host cell. In addition, we explore the potential of sulfated polysaccharides as antiviral agents in preventing recent Corona Virus Disease-2019 (COVID-19). © 2020 Elsevier Ltd
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