Caseinate-coated zein nanoparticles as potential delivery vehicles for guavinoside B from guava: Molecular interactions and encapsulation properties

被引：2

作者：

Yang, Haoning ^{[1
,3
]}

Mu, Yu ^{[1
,3
]}

Zheng, Dan ^{[1
,3
]}

Puopolo, Tess ^{[2
]}

Zhang, Lejie ^{[1
,3
]}

Zhang, Zhuo ^{[1
,3
]}

Gao, Sai ^{[1
,3
]}

Seeram, Navindra P. ^{[2
]}

Ma, Hang ^{[2
]}

Huang, Xueshi ^{[1
,3
]}

Li, Liya ^{[1
,3
]}

机构：

[1] Northeastern Univ, Inst Microbial Pharmaceut, Coll Life & Hlth Sci, Shenyang 110819, Peoples R China

[2] Univ Rhode Isl, Coll Pharm, Dept Biomed & Pharmaceut Sci, Bioact Bot Res Lab, Kingston, RI 02881 USA

[3] Northeastern Univ, Coll Life & Hlth Sci, Key Lab Bioresource Res & Dev Liaoning Prov, Shenyang 110819, Peoples R China

来源：

FOOD CHEMISTRY | 2024年 / 456卷

基金：

中国国家自然科学基金;

关键词：

Guavinoside B; Zein; Nanoparticles; Interaction mechanism; Antioxidant activity; SODIUM CASEINATE; ETHANOL;

D O I：

10.1016/j.foodchem.2024.140066

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Guavinoside B (GUB) is a characteristic constituent from guava with strong antioxidant activity; however, its low water solubility limits its utilization. Herein, we investigated the interaction between GUB and zein, a prolamin with self-assembling property, using multiple spectroscopic methods and fabricated GUB-zein-NaCas nanoparticles (GUB-Z-N NPs) via the antisolvent coprecipitation approach. GUB caused fluorescence quenching to zein via the static quenching mechanism. Fourier-transform infrared spectroscopy and computational analysis revealed that GUB bound to zein via van der Waals interaction, hydrogen bond, and hydrophobic forces. The GUB-Z-N NPs were in the nanometric size range (< 200 nm) and exhibited promising encapsulation efficiency and redispersibility after freeze-drying. These particles remained stable for up to 31 days at 4 C-degrees and great resistance to salt and pH variation, and displayed superior antioxidant activity to native GUB. The current study highlights the potential of zein-based nanoparticles as delivery vehicles for GUB in the food industry.

引用

页数：11

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