Aligned 3D porous polyurethane scaffolds for biological anisotropic tissue regeneration

被引：0

作者：

Lin W. ^{[1
]}

Lan W. ^{[2
]}

Wu Y. ^{[1
]}

Zhao D. ^{[2
]}

Wang Y. ^{[3
]}

He X. ^{[4
]}

Li J. ^{[1
]}

Li Z. ^{[1
]}

Luo F. ^{[1
]}

Tan H. ^{[1
]}

Fu Q. ^{[1
]}

机构：

[1] College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu

[2] Sichuan Institute for Food and Drug Control, Chengdu

[3] Department of Neurosurgery West China Hospital, Sichuan University, Chengdu

[4] Laboratory Animal Center of Sichuan University, Chengdu

来源：

Regenerative Biomaterials | 2019年 / 7卷 / 01期

关键词：

aligned scaffolds; anisotropic regeneration; polyurethane; tissue engineering;

D O I：

10.1093/rb/rbz0314

中图分类号：

学科分类号：

摘要：

A green fabrication process (organic solvent-free) of artificial scaffolds is required in tissue engineering field. In this work, a series of aligned three-dimensional (3D) scaffolds are made from biodegradable waterborne polyurethane (PU) emulsion via directional freeze-drying method to ensure no organic byproducts. After optimizing the concentration of polymer in the emulsion and investigating different freezing temperatures, an aligned PUs scaffold (PU14) generated from 14 wt% polymer content and processed at -196°C was selected based on the desired oriented porous structure (pore size of 32.5 ± 9.3 μm, porosity of 92%) and balanced mechanical properties both in the horizontal direction (strength of 41.3 kPa, modulus of 72.3 kPa) and in the vertical direction (strength of 45.5 kPa, modulus of 139.3 kPa). The response of L929 cells and the regeneration of muscle tissue demonstrated that such pure material-based aligned 3D scaffold can facilitate the development of orientated cells and anisotropic tissue regeneration both in vitro and in vivo. Thus, these pure material-based scaffolds with ordered architecture have great potentials in tissue engineering for biological anisotropic tissue regeneration, such as muscle, nerve, spinal cord and so on. © 2019 The Author(s) 2019. Published by Oxford University Press.

引用

页码：19 / 27

页数：8

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