Preparation and Mechanical Properties of Polycaprolactone Enhancement β-tricalcium Phosphate Composite Scaffold

被引：0
|
作者：
Chen R. [1 ,2 ]
Wu Y. [2 ,3 ]
Zhao G. [2 ]
机构：
[1] Key Lab of Intelligent Equipment Digital Design and Process Simulation, Tangshan University, Hebei, Tangshan
[2] State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an
[3] School of Mechatronic Engineering and Automation, Foshan University, Guangdong, Foshan
来源：
Hsi-An Chiao Tung Ta Hsueh/Journal of Xi'an Jiaotong University | 2024年 / 58卷 / 03期
关键词：
large bone defects; mechanical properties; micromorphology; polycaprolactone coating; β-tri calcium phosphate composite scaffold;
D O I：
10.7652/xjtuxb202403012
中图分类号：
学科分类号：
摘要：
To address the insufficient toughness of bioceramics in the repair and reconstruction of large bone defects, a bioceramic β-tricalcium phosphate/polycaprolactone composite scaffold with high strength and toughness is fabricated using digital light processing technology and coating techniques. The effects of the concentration of polycaprolactone coating on the compressive and flexural properties and microstructure of the composite scaffold are studied. The results show that polycaprolactone coating effectively improves the mechanical properties of the β-tricalcium phosphate ceramic scaffold. Both the strength and toughness of the composite scaffold are positively correlated with the concentration of polycaprolactone coating. The reliability of the composite scaffold is improved and coating effectiveness is enhanced significantly with the increase of coating concentration, but unevenness becomes more pronounced. The evaluation of mechanical properties and microstructural morphology shows that the composite scaffold with a polycaprolactone concentration of 0.20 g/mL exhibits the best overall performance. This study lays a foundation for the fabrication of composite scaffolds that meet the mechanical property requirements of both bone growth and bone reinforcement stages. © 2024 Xi'an Jiaotong University. All rights reserved.
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页码：129 / 136
页数：7
相关论文
共 24 条
  • [1] XIN Lei, SU Jiacan, Current status and prospect of artificial bone repair materials, Journal of Traumatic Surgery, 13, 3, pp. 272-275, (2011)
  • [2] WEI Zhangao, XU Linghan, WU Zichen, Et al., Application of inorganic nonmetallic artificial bone materials in vivo, Chinese Journal of Tissue Engineering Research, 26, 16, pp. 2584-2589, (2022)
  • [3] CAO Shuaishuai, HAN J, SHARMA N, Et al., In vitro mechanical and biological properties of 3D printed polymer composite and β-tricalcium phosphate scaffold on human dental pulp stem cells, Materials, 13, 14, (2020)
  • [4] DIENEL K E G, VAN BOCHOVE B, SEPPALA J V., Additive manufacturing of bioactive poly(trimethylene carbonate)/β-tricalcium phosphate composites for bone regeneration, Biomacromolecules, 21, 2, pp. 366-375, (2020)
  • [5] CUI Jingyuan, CHEN Can, YANG Yang, Et al., Reseach progress of the synthesis and modification of biomedical PLA, New Chemical Materials, 48, 10, pp. 268-272, (2020)
  • [6] BARTNIKOWSKI M, DARGAVILLE T R, IVANOVSKI S, Et al., Degradation mechanisms of polycaprolactone in the context of chemistry, geometry and environment, Progress in Polymer Science, 96, pp. 1-20, (2019)
  • [7] DA FONSECA G F, AVELINO S D O M, MELLO D D C R, Et al., Scaffolds of PCL combined to bioglass: synthesis, characterization and biological performance, Journal of Materials Science: Materials in Medicine, 31, 5, (2020)
  • [8] BOHNER M, SANTONI B L G, DOBELIN N., β-tricalcium phosphate for bone substitution: synthesis and properties, Acta Biomaterialia, 113, pp. 23-41, (2020)
  • [9] ABDAL-HAY A, SHEIKH F A, GOMEZ-CEREZO N, Et al., A review of protein adsorption and bioactivity characteristics of poly e-caprolactone scaffolds in regenerative medicine, European Polymer Journal, 162, (2022)
  • [10] SARETIA S, MACHATSCHEK R, LENDLEIN A., Degradation kinetics of oligo(e-caprolactone)ultrathin films: influence of crystallinity, MRS Advances, 6, 33, pp. 790-795, (2021)
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