Levothyroxine Sodium-Thyroid Hormone Replacement Therapy for Hypothyroidism: A Review of Patent Literature

Background: Levothyroxine Sodium is a thyroid hormone replacement therapy for Hypothyroidism. Levothyroxine Sodium is approved to treat Hypothyroidisim, to sup-press thyroid hormone release from cancerous thyroid nodules, and to prevent the growth of goiters. In addition, it is also used to treat conditions such as myxedema, cretinism, and obesity. Objective: This assessment highlights the overview of the recent patents of Levothyroxine Sodium. This review includes patents grouped in sections like product patents, process pa-tents, and composition-related patents, along with the treatment methodology. The objective of this article is to impel pseudoscientists to all existing patents in a solitary place. Methods: Data were gathered from various internet-based resources, including Pa-tentscope® (WIPO), Worldwide Espacenet® (EPO), Google Patents, and InPASS (Indian patent database). Results: Several new processes and composition-related patents of Levothyroxine Sodium have been reported. Further, due to the problem of photosensitivity, oxidation during de-velopment, and stability of Levothyroxine Sodium formulation, several excipients are tried in these patents to stabilize the same. However, the formulation of Levothyroxine Sodium with better characteristics needs to be developed. Conclusion: Extensive exposure has been carried out towards various processes for the preparation of Levothyroxine Sodium and the composition of the same. This sort of dy-namic exploration will clear the path for many generic players, which will lead to the re-duction of the expense of the composition and accordingly enhance global health care at a less expensive cost. © 2023 Bentham Science Publishers.