Amphiphilic drug–additive systems in aqueous and organic solvent–water mixed media: A comprehensive account on physicochemical properties

被引：0

作者：

Gurung, Jackson ^{[1
]}

Anjudikkal, Jamsheera ^{[1
]}

Pulikkal, Ajmal Koya ^{[1
]}

机构：

[1] Department of Chemistry, National Institute of Technology Mizoram, Chaltlang, Aizawl,796012, India

来源：

Journal of Molecular Liquids | 2021年 / 318卷

关键词：

Additives - Physicochemical properties - Morphology - Phase separation - Organic solvents - Drug delivery;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The physicochemical properties of drugs and drug–additive interactions have great importance to elucidate the pharmacological effect of the drug formulations. Plentiful pharmacologically active molecules are amphiphilic in nature. Knowledge about self-assembly, aggregate morphology as well as size and interfacial/micellar properties of such drugs in presence of pharmaceutical excipients (surfactants, electrolytes, polymers, hydrotropes, etc.) is vital from the fundamental and practical point of view. This article reviews the micellar properties and phase separation of drugs as well as drug–additive systems in aqueous and organic solvent–water mixed media. Results of several pharmaceutical excipients/surfactants assisted drug mixed systems have been analyzed through thermodynamic parameters which provide a comprehensive account on the physicochemical aspects of drug/drug–additives systems. Along with amphiphilic drugs, studies of a few non surface-active drugs have also been reviewed. © 2020 Elsevier B.V.

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