Correlating 3D porous structure in polymer films with mass transport properties using FIB-SEM tomography

被引：0

作者：

Fager C. ^{[1
]}

Gebäck T. ^{[2
]}

Hjärtstam J. ^{[3
]}

Röding M. ^{[2
,4
]}

Olsson A. ^{[3
]}

Lorén N. ^{[1
,4
]}

von Corswant C. ^{[3
]}

Särkkä A. ^{[2
]}

Olsson E. ^{[1
]}

机构：

[1] Department of Physics, Chalmers University of Technology, Gothenburg

[2] Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg

[3] AstraZeneca R&D Mölndal

[4] RISE Research Institutes of Sweden, Agriculture and Food, Gothenburg

来源：

Chemical Engineering Science: X | 2021年 / 12卷

关键词：

Focused ion beam; Mass transport; Polymer; Scanning electron microscopy; Soft material; Three dimensional;

D O I：

10.1016/j.cesx.2021.100109

中图分类号：

学科分类号：

摘要：

Porous polymer coatings are used to control drug release from pharmaceutical products. The coating covers a drug core and depending on the porous structure, different drug release rates are obtained. This work presents mass transport simulations performed on porous ethyl cellulose films with different porosities. The simulations were performed on high spatial resolution 3D data obtained using a focused ion beam scanning electron microscope. The effective diffusion coefficient of water was determined using a diffusion chamber. Lattice Boltzmann simulations were used to simulate water diffusion in the 3D data. The simulated coefficient was in good agreement with the measured coefficient. From the results it was concluded that the tortuosity and constrictivity of the porous network increase with decreasing amount of added hydroxypropyl cellulose, resulting in a sharp decrease in effective diffusion. This work shows that high spatial resolution 3D data is necessary, and that 2D data is insufficient, in order to predict diffusion through the porous structure with high accuracy. © 2021 The Authors

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