Bisphenol A decreases the developmental toxicity and histopathological alterations caused by polystyrene nanoplastics in developing marine medaka Oryzias melastigma

被引：3

作者：

Yu F. ^{[1
,2
]}

Jin F. ^{[2
]}

Cong Y. ^{[2
]}

Lou Y. ^{[2
]}

Li Z. ^{[2
]}

Li R. ^{[2
]}

Ding B. ^{[1
]}

Wang Y. ^{[2
]}

Chen J. ^{[3
]}

Wang J. ^{[2
]}

机构：

[1] School of Chemical Engineering, Dalian University of Technology, Dalian

[2] Key Laboratory for Ecological Environment in Coastal Areas (Ministry of Ecology and Environment), Marine Debris and Microplastic Research Center, Department of Marine Chemistry, National Marine Environmental Monitoring Center, Dalian

[3] Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), Key Laboratory on Chemicals Risk Control and Pollution Prevention Technology, School of Environmental Science and Technology, Dalian University of Technology, Dalia

来源：

Chemosphere | 2023年 / 336卷

基金：

中国国家自然科学基金;

关键词：

Bisphenol A; Co-exposure; Embryos; Larvae; Marine fish; Polystyrene;

D O I：

10.1016/j.chemosphere.2023.139174

中图分类号：

学科分类号：

摘要：

Nanoplastics (NPs) are emerging pollutants posing risks to marine biota and human health due to their small size and high bioavailability. However, there are still knowledge gaps regarding effects of co-existing pollutants on NPs toxicity to marine organisms at their respective environmentally relevant concentrations. Herein we investigated developmental toxicity and histopathological alterations caused by co-exposure of polystyrene nanoplastics (PS-NPs) and bisphenol A (BPA) to marine medaka, Oryzias melastigma. Embryos at 6 h post-fertilization were exposed to 50-nm PS-NPs (55 μg/L) or BPA (100 μg/L) or co-exposed to a combination of both. Results showed that PS-NPs exhibited decreased embryonic heart rate, larval body length, and embryonic survival as well as larval deformities such as hemorrhaging and craniofacial abnormality. When co-exposed, BPA mitigated all the adverse developmental effects caused by PS-NPs. PS-NPs also led to an increase in histopathological condition index of liver with early inflammatory responses, while co-exposure of BPA with PS-NPs did not. Our data suggest that the toxicity reduction of PS-NPs in the presence of BPA might result from the decreased bioaccumulation of PS-NPs caused by the interaction between BPA and PS-NPs. This study unveiled the impact of BPA on the toxicity of nanoplastics in marine fish during early developmental stages and highlight the need of more research on the long-term effects of complex mixtures in the marine environment by applying omics approaches to better understand the toxicity mechanism. © 2023 Elsevier Ltd

引用

共 59 条

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