Determination of six residual organic solvents in setastine hydrochloride by headspace gas chromatography

被引：0

作者：

Xia, Hongying ^{[1
]}

Zhong, Zhenhua ^{[1
]}

Yu, Shishi ^{[1
]}

Pei, Kun ^{[1
]}

Liu, Zhen ^{[1
]}

Cheng, Qizhen ^{[1
]}

机构：

[1] Jiangxi Institute for Drug Control, NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine, Jiangxi Province Engineering Research Center of Drug and Medical Device Quality, Nanchang,330029, China

来源：

Chinese Journal of Analysis Laboratory | 2021年 / 40卷 / 01期

关键词：

Acetone - Gas chromatography - Ionization of gases - Organic solvents;

D O I：

10.13595/j.cnki.issn1000-0720.2020.052303

中图分类号：

学科分类号：

摘要：

A headspace gas chromatography (HS-GC) method was established for the determination of six residual solvents including ethyl ether, acetone, isopropanol, tetrahydrofuran, toluene and xylene in setastine hydrochloride. The sample was disolved in dimethyl sulfoxide, heated at ll0°C for 20 minutes in order to reach the vaporliquid equilibrium state, and detected by flame ionization detector(FID). DB-l70l capillary column (60 m X 0. 320 mm, l. 00 ^m) was used with the column temperature raised by program. Under optimized conditions of HS-GC, the six residual organic solvents were separated well. Good linearities were obtained in the experimental concentration(correlation coefficient; #2 =0. 9998-l. 0000). The average recoveries were in the range from96. 5% to 98.9% ( = 9). The method is suitable for the routine detection of the six residual solvents in setastine hydrochloride. © 2021, Youke Publishing Co.,Ltd. All rights reserved.

引用

页码：70 / 74