Exploring kinase family inhibitors and their moiety preferences using deep SHapley additive exPlanations

被引：0

作者：

Fan, You-Wei ^{[1
]}

Liu, Wan-Hsin ^{[2
,3
,4
]}

Chen, Yun-Ti ^{[2
]}

Hsu, Yen-Chao ^{[2
]}

Pathak, Nikhil ^{[5
]}

Huang, Yu-Wei ^{[6
]}

Yang, Jinn-Moon ^{[2
,7
]}

机构：

[1] Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu,30050, Taiwan

[2] Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu,30050, Taiwan

[3] Institute of Information Science, Academia Sinica, Taipei,11564, Taiwan

[4] Bioinformatics Program, Taiwan International Graduate Program, Academia Sinica, Taipei,11564, Taiwan

[5] Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu,30044, Taiwan

[6] Institute of Biomedical Engineering, National Chiao Tung University, Hsinchu,30050, Taiwan

[7] Department of Biological Science and Technology, National Chiao Tung University, Hsinchu,30050, Taiwan

来源：

BMC Bioinformatics | 2022年 / 23卷

关键词：

Compendex;

D O I：

242

中图分类号：

学科分类号：

摘要：

Deep neural networks - Diseases - Enzyme inhibition - Signal transduction

引用