Photo-sensitized oxy-thiocyanation of terminal alkynes/1,3-aryldienes and their one-pot conversion to 2-hydroxy 4-substituted aryl thiazoles

被引：0
作者：
Gullapalli K. [1 ,2 ]
Vijaykumar S. [1 ]
机构：
[1] Organic Synthesis and Process Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 607, Telangana
[2] Academy of Scientific and Innovative Research (AcSIR), New Delhi
来源：
Organic and Biomolecular Chemistry | 2019年 / 17卷 / 08期
关键词：
Ambient air - Aryl alkynes - Large-scale applications - Non-metallic - One pot - Regio-selective - Terminal alkyne - Visible light induced;
D O I：
10.1039/C9OB00054B
中图分类号：
学科分类号：
摘要：
A regioselective visible light induced synthesis of aryl α-thiocyano ketones/thiocyano alcohols from activated terminal aryl alkynes and aryl 1,3-conjugated dienes was achieved. This mild and non-metallic oxidation is exclusively driven by benign ambient air in the presence of an organic photo-catalyst and NH 4 SCN. This protocol was also demonstrated at the 5 mmol scale for the synthesis of potentially therapeutic 2-hydroxy 4-substituted arylthiazoles in good yields, signifying its amenability for large-scale application. © The Royal Society of Chemistry.
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页码：2232 / 2241
页数：9
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