The effect of bowman-birk inhibitor from soybeans on the sensitivity of prostate cancer stem-like cells to anti-androgen agent

被引：0
|
作者：
Endo D. [1 ]
Kaneko S. [1 ]
Ishii K. [2 ]
Kohno K. [1 ,3 ]
Sato A. [3 ]
Virgona N. [3 ]
Yano T. [1 ,2 ,3 ]
机构：
[1] Graduate School of Food and Nutritional Sciences, Toyo University, 1-1-1 Izumino, Itakura-machi, Oura, Gunma
[2] Faculty of Food and Nutritional Sciences and Toyo University, 1-1-1 Izumino, Itakura-machi, Oura, Gunma
[3] Institute of Life Innovation Studies, Toyo University, 1-1-1 Izumino, Itakura-machi, Oura, Gunma
来源：
Yano, Tomohiro (yano_t@toyo.jp) | 1600年 / Japanese Society for Food Science and Technology卷 / 26期
关键词：
Androgen; Anti-androgen agent; Bowman-Birk inhibitor; Prostate cancer stem cell; Prostate-specific antigen;
D O I：
10.3136/FSTR.26.553
中图分类号：
学科分类号：
摘要：
Prostate stem-like cells exhibit resistance to anti-androgen agents and contribute to the recurrence of this cancer. A novel approach to overcome the resistance of prostate cancer stem-like cells is thus essential. The present study investigated whether soybean derived Bowman-Birk inhibitor (BBI) could abrogate the resistance of prostate cancer stem-like cells from an androgen-dependent prostate cancer cell line (LNCaP cells) to an anti-androgen agent. The LNCaP stem-like cells exhibited stronger resistance to an androgen antagonist, flutamide, than LNCaP parental cells. Exposure of LNCaP stem-like cells to BBI treatment reduced their stemness and resistance to flutamide. In parallel, LNCaP stem-like cells showed a positive response based on changes in the typical androgen-governed gene, prostate-specific antigen. These results suggest the potential of BBI as a candidate to reduce the resistance of prostate cancer stem-like cells to anti-androgen agents. Copyright © 2020, Japanese Society for Food Science and Technology.
引用
收藏
页码：553 / 559
页数：6
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