Synthesis and Antimicrobial Activity Assay of Nanometal Oxide-Doped Liquid Crystal

被引:0
作者
Deepthi S. [1 ]
Srikiran S. [2 ]
Satyanarayana Gupta M. [3 ]
Mulatu Kumara A. [4 ]
机构
[1] Department of Science and Humanities, Lendi Institute of Engineering and Technology, Vizianagaram
[2] Centre for Nanotechnology, Andhra University, College of Engineering, Visakhapatnam
[3] Department of Aeronautical Engineering, MLR Institute of Technology, Telangana, Hyderabad
[4] College of Engineering and Technology, Wollega University, Nekemte
关键词
Antibiotics - Aspergillus - Bacteria - Controlled drug delivery - Fourier transform infrared spectroscopy - Liquid crystals - Scanning electron microscopy - Targeted drug delivery - Transmission electron microscopy;
D O I
10.1155/2023/5668025
中图分类号
学科分类号
摘要
The spread of infectious diseases across the globe as a result of numerous bacterial and fungal variations has become a serious threat to human life. A critical global situation is the need to search for antibiotic resistance and develop new treatments. The most crucial role is for academics to advise the pharmaceutical industry about substances with antimicrobial assessments. One of the challenges in implementing novel medicine delivery is the discovery of compounds having antibacterial and antifungal characteristics against Gram-positive and Gram-negative bacteria and fungi. The superiority of the metal oxide-doped liquid crystal technology for antibiotic resistance is revealed. In this work, a bacterially triggered drug delivery system using a nanometal oxide-doped lipid-based liquid crystal system was explored. Copper oxide (CU) and cholesteryl stearate (CS) are processed using ultrasonication to produce the complex chemical in powder form (CSCU). Functional groups are predicted by Fourier transform infrared (FTIR) analyses, while surface appearance and dimensions that support the compound CSCU's biological characteristics are revealed by scanning electron microscope (SEM) and transmission electron microscope (TEM) analyses. Using the agar-well diffusion method, this substance was tested for antibacterial and antifungal activities against the Gram-positive bacteria Streptococcus pyogenes at various concentrations ranging from 0.6 to 1.25 μg/ml. Additionally, this substance exhibits a range of moderate to good antifungal efficacy against Aspergillus niger. © 2023 S. Deepthi et al.
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