Surface engineering of magnetic nanoparticles for hyperthermia and drug delivery

Magnetic nanoparticles (MNP) have emerged as a relevant material for biomedical applications based on drug delivery systems and magnetic hyperthermia. When carefully tailored, their surface properties can enhance the solubility, bioavailability, permeability, metabolism, excretion, cell internalization and recognition of many medicines, which are parameters highly desired when one think in the development and efficiency increasing of several therapies. Allied to it, an interesting synergism can be achieved by the use of magnetic fields as trigger of drug release from thermosensitive polymer-modified MNP or as a tool to increase accumulation of medicine in specific site. Faced it, here it shows how surface engineering of MNP can improve its biomedical relevance due to enhancement of cellular recognition, biocompatibility and drug release of several medicines. Furthermore, particular attention will be paid to the use of magnetic hyperthermia, which has acted synergic to improve MNP effects of many drug delivery systems. © 2020 Wiley Periodicals LLC