BINOL-derived bifunctional sulfide catalysts for asymmetric synthesis of 3,3-disubstituted phthalides via bromolactonization

被引：0

作者：

Okada M. ^{[1
]}

Kaneko K. ^{[2
]}

Yamanaka M. ^{[2
]}

Shirakawa S. ^{[1
]}

机构：

[1] Department of Environmental Science, Graduate School of Fisheries and Environmental Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki

[2] Department of Chemistry and Research Center for Smart Molecules, Faculty of Science, Rikkyo University, 3-34-1 Nishi-Ikebukuro Toshima-ku, Tokyo

来源：

Organic and Biomolecular Chemistry | 2019年 / 17卷 / 15期

基金：

日本学术振兴会;

关键词：

D O I：

10.1039/C9OB00417C

中图分类号：

学科分类号：

摘要：

An efficient enantioselective synthesis of 3,3-disubstituted phthalides possessing a chiral quaternary carbon center was achieved via catalytic asymmetric bromolactonization that utilized BINOL-derived bifunctional sulfide catalysts. Transformations of the bromo group in optically active phthalide products were also performed to demonstrate the utility of this novel synthetic protocol. © The Royal Society of Chemistry.

引用

页码：3747 / 3751

页数：4

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