BINOL-derived bifunctional sulfide catalysts for asymmetric synthesis of 3,3-disubstituted phthalides via bromolactonization

被引：0
|
作者：
Okada M. [1 ]
Kaneko K. [2 ]
Yamanaka M. [2 ]
Shirakawa S. [1 ]
机构：
[1] Department of Environmental Science, Graduate School of Fisheries and Environmental Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki
[2] Department of Chemistry and Research Center for Smart Molecules, Faculty of Science, Rikkyo University, 3-34-1 Nishi-Ikebukuro Toshima-ku, Tokyo
来源：
Organic and Biomolecular Chemistry | 2019年 / 17卷 / 15期
基金：
日本学术振兴会;
关键词：
D O I：
10.1039/C9OB00417C
中图分类号：
学科分类号：
摘要：
An efficient enantioselective synthesis of 3,3-disubstituted phthalides possessing a chiral quaternary carbon center was achieved via catalytic asymmetric bromolactonization that utilized BINOL-derived bifunctional sulfide catalysts. Transformations of the bromo group in optically active phthalide products were also performed to demonstrate the utility of this novel synthetic protocol. © The Royal Society of Chemistry.
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收藏
页码：3747 / 3751
页数：4
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