Preparation and in vitro drug release of functionalized boron dual drug-loaded nanocomposite

被引：0

作者：

Fu, Zi ^{[1
]}

Zhang, Xuejing ^{[1
]}

Zhu, Limin ^{[1
]}

机构：

[1] College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai,201620, China

来源：

Jingxi Huagong/Fine Chemicals | 2020年 / 37卷 / 04期

关键词：

Boron - Controlled drug delivery - Drug products - Etching - High resolution transmission electron microscopy - Infrared devices - Targeted drug delivery - Thermooxidation;

D O I：

10.13550/j.jxhg.20190851

中图分类号：

学科分类号：

摘要：

Boron nanosheets (B NSs) were prepared by coupling thermal oxidation etching and liquid exfoliation technology. Then, they were modified by H2N-PEG-NH2 to obtain B-PEG nanosheets (B-PEG NSs). Subsequently, B-PEG-cRGD composite was prepared using cyclic RGD (cRGD) tripeptide as monomer, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS) as initiators. Finally, DOX-17AAG@B-PEG-cRGD nano drug-loaded composite was obtained by blending B-PEG-cRGD with doxorubicin (DOX) and heat shock protein 90 inhibitor, 17-allylamin, 17-demethoxygeldanamycin (17AAG). The structure and morphology of B NSs and DOX-17AAG@B-PEG-cRGD composite were characterized by transmission electron microscopy (TEM), ultraviolet spectrophotometer and dynamic light scattering (DLS). The results show that DOX-17AAG@B-PEG-cRGD composite has good stability with a hydrodynamic average diameter of about 184 nm. The in vitro drug release studies reveal that the composite has near-infrared light (NIR) and pH double responsiveness, as well as exhibits good drug sustained release effect. When the in vitro drug release experiment was carried out at pH=5.0 and NIR irradiation for 72 h, the cumulative release rates of DOX and 17AAG were up to 66.53% and 73.01%, respectively. © 2020, Editorial Office of FINE CHEMICALS. All right reserved.

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页码：779 / 784