Asymmetric Synthesis of Chiral Seven-Membered NHCs, Their Transition-Metal Complexes and Application in Asymmetric Catalysis

被引：2
作者：
Han J. [1 ,2 ]
Pan Y. [1 ]
Hao W. [1 ]
Fan Q.-H. [1 ,2 ]
机构：
[1] Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing
[2] University of Chinese Academy of Sciences, Beijing
来源：
Synthesis (Germany) | 2023年 / 55卷 / 14期
关键词：
8,8′-biquinolines; asymmetric hydrogenation; carbene complexes; chiral NHCs; hydrosilylation;
D O I：
10.1055/s-0042-1751439
中图分类号：
学科分类号：
摘要：
A series of new chiral seven-membered NHCs were synthesized via Ru-catalyzed asymmetric hydrogenation reactions as the key step. Transition metal such as Rh, Ir and Au can coordinate to the developed NHCs. The crystal structures of the chiral seven-membered NHCs and their transition-metal complexes show a nonplanar framework with torsional twist. Furthermore, the chiral NHCs were applied in asymmetric hydrosilylation reactions, and the corresponding product was obtained with >95% yield and up to 83% ee. © 2023 Georg Thieme Verlag. All rights reserved.
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页码：2206 / 2218
页数：12
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