Cerebral blood flow analysis based on laser speckle contrast imaging technology

被引：0
|
作者：
Wu D.-D. [1 ,2 ]
Yao K. [2 ]
Guan K.-J. [2 ]
Fu W.-W. [2 ,3 ]
Sun J.-M. [1 ]
Guo Y.-B. [4 ]
Wang C. [1 ]
机构：
[1] School of Mechatronic Engineering and Automation, Shanghai University, Shanghai
[2] Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou
[3] Suzhou Guoke Medical Technology Development (Group) Co., Ltd., Suzhou
[4] Bethune First Hospital of Jilin University, Changchun
来源：
Guangxue Jingmi Gongcheng/Optics and Precision Engineering | 2020年 / 28卷 / 11期
关键词：
Blood flow; Blood vessel diameter; Laser speckle; Laser technique; Time contrast;
D O I：
10.37188/OPE.20202811.2411
中图分类号：
学科分类号：
摘要：
During cerebrovascular surgery, it is necessary to monitor the flow velocity and the flow in the target blood vessel. In this study, a method of cerebral blood flow analysis based on laser speckle contrast imaging (LSCI) technology was investigated to evaluate the blood flow conditions and cerebral blood flow perfusion after vascular anastomosis. First, the LSCI system was developed to acquire speckle images, and the blood flow velocity image was captured through improved time contrast analysis and pseudocolor processing to monitor the change in flow velocity. Next, the reference points of the region of interest (ROI) were manually selected to intercept the ROI. After the image preprocessing of the ROI was carried out, the improved Canny algorithm was used to extract the edge line of the blood vessel and calculate the blood vessel diameter. Finally, reliability for blood-flow velocity-change monitoring and blood-vessel diameter measurement functions of the LSCI system were verified through animal experiments. The experimental results showed that the improved Canny algorithm decreased the relative error of the vessel diameter to 5.1%. The cerebral blood flow analysis method based on LSCI technology is suitable for monitoring variations in blood flow velocity and measuring the effective flow diameter of blood vessels. When the proposed method is combined with a laser Doppler blood flow meter, blood flow velocity and flow during surgery can be monitored accurately. © 2020, Science Press. All right reserved.
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页码：2411 / 2420
页数：9
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