Ultrasound-assisted extraction of asiaticoside from Centella asiatica using betaine-based natural deep eutectic solvent

被引:20
作者
Mohd Fuad F. [1 ,2 ]
Mohd Nadzir M. [1 ]
机构
[1] School of Chemical Engineering, Universiti Sains Malaysia, Engineering Campus, Nibong Tebal, Pulau Pinang
[2] School of Chemical Engineering, College of Engineering, Universiti Teknologi MARA, Selangor, Shah Alam
关键词
Centella asiatica; Kinetic; Natural deep eutectic solvent; Response surface methodology; Ultrasound;
D O I
10.1016/j.indcrop.2022.116069
中图分类号
学科分类号
摘要
Centella asiatica is known for its valuable medicinal properties which highlight its potential application in the pharmaceutical industry. In this work, the ultrasound-assisted extraction (UAE) of asiaticoside from C. asiatica using betaine-based natural deep eutectic solvents (NADES) was developed for the first time. Eleven different NADES were screened to determine the best solvent to extract asiaticoside. Betaine-levulinic acid (Bet-Lev) at a molar ratio of 1:2 with water content of 30% (w/w) was selected as the most effective solvent. The influence of extraction time, temperature, ultrasound power, and liquid to solid (L/S) ratio were investigated in single-factor experiments. These parameters were optimized using response surface methodology (RSM) via the Box-Behnken design (BBD). The optimum conditions were 32 min extraction time, 36 °C extraction temperature, 140 W ultrasound power, and 49 mL/g L/S ratio to give an extraction yield of 229.92 ± 1.67 mg/g. A second order model was used to study the kinetics of asiaticoside extraction. Furthermore, the mechanisms involved in the extraction process were proposed and discussed. The morphology of C. asiatica powder was analysed before and after the extraction. A comparative study confirmed that the optimized UAE-NADES technique provided higher yield than that of the conventional extraction method. © 2022 Elsevier B.V.
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  • [1] Abbas M., Ahmed D., Qamar M.T., Ihsan S., Noor Z.I., Optimization of ultrasound-assisted, microwave-assisted and Soxhlet extraction of bioactive compounds from Lagenaria siceraria: a comparative analysis, Bioresour. Technol. Rep., 15, (2021)
  • [2] Abbott A.P., Capper G., Davies D.L., Rasheed R.K., Tambyrajah V., Novel solvent properties of choline chloride/urea mixtures, Chem. Commun., pp. 70-71, (2003)
  • [3] Abbott A.P., Boothby D., Capper G., Davies D.L., Rasheed R.K., Deep eutectic solvents formed between choline chloride and carboxylic acids: versatile alternatives to ionic liquids, J. Am. Chem. Soc., 126, pp. 9142-9147, (2004)
  • [4] Abbott A.P., Harris R., Ryder K., D'Agostino C., Gladden L., Mantle M., Glycerol eutectics as sustainable solvent systems, Green. Chem., 13, pp. 82-90, (2011)
  • [5] Abranches D.O., Silva L.P., Martins M.A.R., Pinho S.P., Coutinho J.A.P., Understanding the formation of deep eutectic solvents: betaine as a universal hydrogen bond acceptor, ChemSusChem, 13, pp. 4916-4921, (2020)
  • [6] Acevedo-Paez J.C., Duran J.M., Posso F., Arenas E., Hydrogen production from palm kernel shell: Kinetic modeling and simulation, Int. J. Hydrog. Energy, 45, pp. 25689-25697, (2020)
  • [7] Autor E., Cornejo A., Bimbela F., Maisterra M., Gandia L.M., Martinez-Merino V., Extraction of phenolic compounds from populus salicaceae bark, Biomolecules, 12, (2022)
  • [8] Bener M., Sen F.B., Onem A.N., Bekdeser B., Celik S.E., Lalikoglu M., Asci Y.S., Capanoglu E., Apak R., Microwave-assisted extraction of antioxidant compounds from by-products of Turkish hazelnut (Corylus avellana L.) using natural deep eutectic solvents: modeling, optimization and phenolic characterization, Food Chem., 385, (2022)
  • [9] Carbone K., Macchioni V., Petrella G., Cicero D.O., Exploring the potential of microwaves and ultrasounds in the green extraction of bioactive compounds from Humulus lupulus for the food and pharmaceutical industry, Ind. Crop. Prod., 156, (2020)
  • [10] Chakraborty S., Uppaluri R., Das C., Optimization of ultrasound-assisted extraction (UAE) process for the recovery of bioactive compounds from bitter gourd using response surface methodology (RSM, Food Bioprod. Process., 120, pp. 114-122, (2020)