Synthesis and Characterisation of Piperine-loaded Starch Nanoparticles

被引：10

作者：

Chong, Wan-Hong ^{[1
]}

Chin, Suk-Fun ^{[1
]}

Pang, Suh-Cem ^{[1
]}

Kok, Kuan-Ying ^{[2
]}

机构：

[1] Univ Malaysia Sarawak, Fac Resource Sci & Technol, Kota Samarahan 94300, Sarawak, Malaysia

[2] Agensi Nuklear Malaysia, Kajang 43000, Selangor, Malaysia

来源：

JOURNAL OF PHYSICAL SCIENCE | 2020年 / 31卷 / 01期

关键词：

Piperine; starch nanoparticles; nanocarriers; release studies; syhthesis and characterisation;

D O I：

10.21315/jps2020.31.1.4

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This study aimed to explore the potential application of starch nanoparticles as the nanocarriers for the controlled release of piperine. Starch nanoparticles with mean particle sizes ranging from 50 nm to 200 nm have been synthesised as nanocarriers for encapsulation of piperine. Piperine has been successfully loaded onto starch nanoparticles via the in-situ nanoprecipitation method. The loading capacity of piperine was affected by the synthesis conditions such as types and concentrations of surfactants as well as initial piperine concentrations. Under optimum conditions, starch nanoparticles exhibited a maximum piperine loading capacity of 4.74 mg mg(-1). Piperine was observed to release out from starch nanoparticles in a slow and steady manner over a period of 168 h under physiological pH.

引用

页码：57 / 68

页数：12

共 16 条

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