Progress on the roles of glia in postoperative cognitive dysfunction

术后认知功能障碍（POCD）是全麻手术术后常见的并发症之一，主要表现为术后新发的认知功能受损，但目前 POCD 的发病机制仍不完全明确。胶质细胞是神经组织中除神经元以外的另一大类细胞，主要包括小胶质细胞、星形胶质细胞和少突胶质细胞等。胶质细胞与神经元的双边信号传导是维持神经系统功能运转的重要基础。最新研究表明胶质细胞的功能失常可能参与 POCD 的发生及发展。本文综述了近年相关研究，为其发病机制及防治策略的探讨提供新思路。.; Postoperative cognitive dysfunction (POCD) is one of the most common complications after surgery under general anesthesia and usually manifests as newly presented cognitive impairment. However, the mechanism of POCD is still unclear. In addition to neurons, glial cells including microglia, astrocytes and oligodendrocytes, represent a large cell population in the nervous system. The bi-directional communication between neurons and glia provides basis for neural circuit function. Recent studies suggest that glial dysfunctions may contribute to the occurrence and progress of POCD. In this paper, we review the relevant work on POCD, which may provide new insights into the mechanism and therapeutic strategy for POCD.