Preparation and Self-assembly Behaviors of Amphiphilic Cyclic Brush Copolymers with Core-shell-corona Structure

被引：0
|
作者：
Tu X. [1 ]
Liu W. [1 ]
Wei H. [2 ]
机构：
[1] Lanzhou Petrochemical Research Center, Petrochemical Research Institute, Petrochina, Lanzhou
[2] College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou
来源：
Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering | 2020年 / 36卷 / 07期
关键词：
Core-shell-corona structure; Cyclic brush copolymer; Drug release; Self-assemble;
D O I：
10.16865/j.cnki.1000-7555.2020.0154
中图分类号：
学科分类号：
摘要：
Amphiphilic cyclic brush polymers, poly(2-hydroxyethyl methacrylate-g-poly(ε-caprolactone)-poly(oligoethyleneglycol methacrylate)) (P(HEMA-g-PCL18-POEGMA)50) were designed and synthesized successfully via a "grafting from" approach using sequential ATRP and ring-opening polymerization (ROP) from a cyclic multimacroinitiator PHEMA. The structures of polymers were characterized by 1H-NMR spectrometer and SEC-MALLS. Dynamic light scatting (DLS) determination reveals that amphiphilic cyclic brush copolymers with different POEGMA chain lengths could form stable polymeric micelles. Critical aggregation concentration (CAC) result reveals that P(HEMA-g-PCL18-POEGMA30)50 has the highest stability. TEM result demonstrates that P(HEMA-g-PCL18-POEGMA30)50 can be self-assembled into spherical nanoparticles and has good dispersity. In vitro drug release study reveals that DOX-loaded nanoparticles are stable with dithiothreitol (DTT) and without DTT. © 2020, Editorial Board of Polymer Materials Science & Engineering. All right reserved.
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页码：23 / 30
页数：7
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