Silver nanoparticle based multifunctional approach for combating COVID-19

被引：45
作者：
Allawadhi P. [1 ]
Singh V. [2 ]
Khurana A. [3 ,4 ,5 ]
Khurana I. [6 ]
Allwadhi S. [7 ]
Kumar P. [8 ]
Banothu A.K. [4 ,9 ]
Thalugula S. [10 ]
Barani P.J. [11 ]
Naik R.R. [12 ]
Bharani K.K. [5 ,9 ]
机构：
[1] Department of Pharmacy, Vaish Institute of Pharmaceutical Education and Research (VIPER), Pandit Bhagwat Dayal Sharma University of Health Sciences (Pt. B. D. S. UHS), Rohtak - 124001, Haryana
[2] Department of Biotechnology, Indian Institute of Technology (IIT) Roorkee, Roorkee - 247667, Uttarakhand
[3] Centre for Biomedical Engineering (CBME), Indian Institute of Technology (IIT) Delhi, Hauz Khas
[4] Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science (CVSc), Rajendranagar, PVNRTVU, Hyderabad - 500030, Telangana
[5] Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science (CVSc), PVNRTVU, Warangal - 506166, Telangana
[6] Department of Pharmaceutical Chemistry, University Institute of Pharmaceutical Sciences (UIPS), Panjab University
[7] Department of Computer Science and Engineering, University Institute of Engineering and Technology (UIET), Maharshi Dayanand University (MDU), Rohtak - 124001, Haryana
[8] Department of Radiation Oncology, Regional Cancer Centre, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences (Pt. B. D. S. PGIMS), Rohtak - 124001, Haryana
[9] Department of Aquatic Animal Health Management, College of Fishery Science, Pebbair, PVNRTVU, Wanaparthy - 509104, Telangana
[10] Department of Pharmacology, University College of Pharmaceutical Sciences (UCPS), Kakatiya University, Warangal - 506009, Telangana
[11] Department of Chemistry, Wesley Degree College for Women, Osmania University, Secunderabad - 500025, Telangana
[12] Zaney Pharma Innovations, Tarnaka, Hyderabad - 500007, Telangana
来源：
Sensors International | 2021年 / 2卷
关键词：
Antimicrobial; Antiviral activity; COVID-19; Cytokine storm; Silver nanoparticles;
D O I：
10.1016/j.sintl.2021.100101
中图分类号：
学科分类号：
摘要：
COVID-19 is a highly contagious and widespread disease that has strained the global healthcare system to the hilt. Silver nanoparticles (AgNPs) are well known for their potent antimicrobial, antiviral, immunomodulatory and biosensing properties. AgNPs have been found to be potential antiviral agent that act against many deadly viruses and is presumed to be effective against COVID-19. AgNPs can generate free radicals and reactive oxygen species (ROS) leading to apoptosis mediated cell death thereby inhibiting viral infection. The shape and size of AgNPs play an important role in its biomedical applications as alterations may result in variable biological interaction and activity. Herein, we propose that AgNPs can be utilized for effective management of the ongoing COVID-19 pandemic by highlighting the current status of AgNPs in the fight against COVID-19. © 2021 The Authors
引用
收藏
相关论文
共 85 条
[51]  
Wong K.K., Et al., Further evidence of the anti-inflammatory effects of silver nanoparticles, ChemMedChem, 4, 7, pp. 1129-1135, (2009)
[52]  
Gonzalez-Carter D.A., Et al., Silver nanoparticles reduce brain inflammation and related neurotoxicity through induction of H2S-synthesizing enzymes, Sci. Rep., 7, 1, (2017)
[53]  
Hebeish A., Et al., Antimicrobial wound dressing and anti-inflammatory efficacy of silver nanoparticles, Int. J. Biol. Macromol., 65, pp. 509-515, (2014)
[54]  
Asgharzadeh F., Et al., Therapeutic effects of silver nanoparticle containing sulfasalazine on DSS-induced colitis model, J. Drug Deliv. Sci. Technol., (2020)
[55]  
Lansdown A.
[56]  
Bhol K.C., Alroy J., Schechter P.J., Anti-inflammatory effect of topical nanocrystalline silver cream on allergic contact dermatitis in a Guinea pig model, Clin. Exp. Dermatol., 29, 3, pp. 282-287, (2004)
[57]  
Morris D., Et al., Antiviral and immunomodulatory activity of silver nanoparticles in experimental RSV infection, Viruses, 11, 8, (2019)
[58]  
Greulich C., Et al., Cell type-specific responses of peripheral blood mononuclear cells to silver nanoparticles, Acta Biomater., 7, 9, pp. 3505-3514, (2011)
[59]  
Greulich C., Et al., Studies on the biocompatibility and the interaction of silver nanoparticles with human mesenchymal stem cells (hMSCs), Langenbeck's Arch. Surg., 394, 3, pp. 495-502, (2009)
[60]  
Abdellatif A.A.H., Rasheed Z., Silver citrate nanoparticles inhibit PMA-induced TNFα expression via deactivation of NF-κB activity in human cancer cell-lines, MCF-7, 15, pp. 8479-8493, (2020)
123456789