Studies on Antioxidant Activity, Hypoglycemic and Lipid-lowering Capacity of Flavonoids in Sweet Orange Peels in Vitro

被引：0
|
作者：
Yao X. [1 ]
Li P. [1 ]
Gu Q. [1 ]
机构：
[1] College of Food Science and Biotechnology, Zhejiang Gongshang University, Key Laboratory for Food Microbial Technology of Zhejiang Province, Hangzhou
来源：
Journal of Chinese Institute of Food Science and Technology | 2022年 / 22卷 / 01期
关键词：
Antioxidant activity; Component content; Hypoglycemic and lipid-lowering; Sweet orange peels flavonoids;
D O I：
10.16429/j.1009-7848.2022.01.006
中图分类号：
学科分类号：
摘要：
This study aims to explore the potential utilization of sweet orange peels. In this paper, flavonoid compounds in the peels of blood orange, navel orange, egyptian orange, and sunkist orange were extracted, and the contents of 11 flavonoid compounds were analyzed by HPLC. Then the bioactive functions in four sweet orange peels were investigated in vitro. The results manifested that there were abundant flavanone compounds in the sweet orange peels, such as eriocitrin, narirutin, and hesperidin, and the contents of polymethoxyflavonoids were less than that of flavanone compounds. The comprehensive APC index of flavonoids in sweet orange peels ranged from 86.20% to 99.47%. The inhibitory ratio of α-glucosidase varying from 46.16% to 70.18%. Moreover, the bile acid salt binding experiment indicated that sweet orange peels flavonoids could bind bile acid sodium, sodium taurocholate, and sodium glycocholate. The adsorption capacity was within the range of 0.359 to 0.460 μmol/mg. Pearson correlation analysis showed positive correlations between the biological activity and the total content of 11 flavonoids. This study provided theoretical support for the development of antioxidative, hypoglycemic, and lipid-lowering functional products using sweet orange peels. © 2022, Editorial Office of Journal of CIFST. All right reserved.
引用
收藏
页码：49 / 57
页数：8
相关论文
共 25 条
  • [1] LIEW S S, HO W Y, YEAP S K, Et al., Phytochemical composition and in vitro antioxidant activities of Citrus sinensis peel extracts, PeerJ, 6, (2018)
  • [2] EL-HADARY A E, RAMADAN M F., Phenolic profiles, antihyperglycemic, antihyperlipidemic, and antioxidant properties of pomegranate (Punica granatum) peel extract, Journal of Food Biochemistry, 43, 4, (2019)
  • [3] DAS G, PATRA J K, BASAVEGOWDA N, Et al., Comparative study on antidiabetic, cytotoxicity, antioxidant and antibacterial properties of biosynthesized silver nanoparticles using outer peels of two varieties of Ipomoea batatas (L.) Lam, International Journal of Nanomedicine, 14, pp. 4741-4754, (2019)
  • [4] RENGASAMY K R R, KHAN H, GOWRISHANKAR S, Et al., The role of flavonoids in autoimmune diseases: Therapeutic updates, Pharmacology & Therapeutics, 194, pp. 107-131, (2019)
  • [5] OTEIZA P I, FRAGA C G, MILLS D A, Et al., Flavonoids and the gastrointestinal tract: Local and systemic effects, Molecular Aspects of Medicine, 61, pp. 41-49, (2018)
  • [6] PEREZ-VIZCAINO F, FRAGA C G., Research trends in flavonoids and health, Archives of Biochemistry and Biophysics, 646, pp. 107-112, (2018)
  • [7] CHEN Q, WANG D, TAN C, Et al., Profiling of flavonoid and antioxidant activity of fruit tissues from 27 Chinese local citrus cultivars, Plants (Basel), 9, 2, (2020)
  • [8] CHEN X, TAIT A R, KITTS D D., Flavonoid composition of orange peel and its association with antioxidant and anti-inflammatory activities, Food Chemistry, 218, pp. 15-21, (2017)
  • [9] BARRECA D, GATTUSO G, BELLOCCO E, Et al., Flavanones: Citrus phytochemical with health-promoting properties, BioFactors (Oxford, England), 43, 4, pp. 495-506, (2017)
  • [10] GANDHI G R, VASCONCELOS A B S, WU D, Et al., Citrus flavonoids as promising phytochemicals targeting diabetes and related complications: A systematic review of in vitro and in vivo studies, Nutrients, 12, 10, (2020)
123