Effect of Rich GABA of Germinated Adzuki Bean on Intestinal Microflora in T2DM Mice

被引：0

作者：

Jiang X. ^{[1
,2
]}

Zhang J. ^{[1
]}

Li Y. ^{[1
]}

Chi X. ^{[1
]}

Sun D. ^{[3
]}

Cao D. ^{[1
,4
]}

Zhang D. ^{[1
,4
]}

机构：

[1] College of Food Science, Heilongjiang Bayi Agricultural University, Daqing

[2] Supervision,Inspection and Testing Center for Agricultural Products and Processed Products, Ministry of Agriculture and Rural Affairs, Daqing

[3] College of Animal Science and Technology, University of Heilongjiang Bayi Agricultural University, Daqing

[4] National Research for Grain Engineering Technology, Heilongjiang Bayi Agricultural University, Daqing

来源：

Science and Technology of Food Industry | 2024年 / 45卷 / 12期

关键词：

adzuki bean; GABA; germinating; intestinal microflora; T2DM;

D O I：

10.13386/j.issn1002-0306.2023120301

中图分类号：

学科分类号：

摘要：

In order to study the effects of GABA-rich germinated adzuki bean on blood glucose level and intestinal flora in T2DM mice. C57BL/6J mice were used as subjects to construct T2DM model by high fat diet+STZ injection. Different doses of GABA-rich germinated adzuki bean were used to treat T2DM mice for 6 weeks and 16S rRNA sequencing technique was used to identify the microbial structure and distribution in the cecal contents of T2DM mice. The results showed that different doses of GABA-rich adzuki bean dietary intervention could significantly reduce the FBG value of T2DM mice, and the FBG value of high dose GABA-rich adzuki bean (TF3) group was 8.36±0.78 mmol/L, which was 54.09%, lower than that of model group (M). In addition, TF3 diet induced significant changes in intestinal flora abundance in T2DM mice. Firmicutes abundance at gate level was 35.96%, which decreased by 53.17% compared with M model group, and Bacteroidetes and Verrucomicrobia abundance were significantly up-regulated. In summary, the improvement of glucose and lipid metabolism by TF3 diet was significantly correlated with the abundance of dominant bacteria in Bacteroidetes and Verrucomicrobia, suggesting that high dose of GABA-rich adzuki bean diet could alleviate hyperglycemia symptoms in T2DM mice through beneficial bacteria, which provided reference for further explaining the relationship between T2DM and intestinal flora. © 2024 Editorial Department of Science and Technology of Food Science. All rights reserved.

引用

页码：151 / 159

页数：8

共 32 条

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