Additive effects of microplastics on accumulation and toxicity of cadmium in male zebrafish

被引：19
作者：
Al Marshoudi M. [1 ,2 ]
Al Reasi H.A. [1 ,3 ]
Al-Habsi A. [1 ]
Barry M.J. [1 ]
机构：
[1] Biology Department, Sultan Qaboos University, PO Box 36, 123, Muscat
[2] Current Address: College of Applied Sciences and Pharmacy, University of Technology and Applied Sciences (UTA), PO Box 74, Al-Khuwair, Muscat
[3] Center for Environmental Studies and Research, Sultan Qaboos University, Al-Khod, PO Box: 17, Muscat
来源：
Chemosphere | 2023年 / 334卷
关键词：
Behavior; Bioaccumulation; Co-exposure; Histopathology; Metallothionein; Vectors;
D O I：
10.1016/j.chemosphere.2023.138969
中图分类号：
学科分类号：
摘要：
Microplastics (MPs) have emerged as contaminants of concern because of their ubiquitous presence in almost all aquatic environments. The ecological effects of MPs are complex and depend on multiple factors including their age, size and the ecological matrix. There is an urgent need for multifactorial studies to elucidate their impacts. We measured the effects of virgin and naturally aged MPs, alone, pretreated with cadmium (Cd), or in combination with ionic Cd, on the bioaccumulation of Cd, metallothionein expression, behavior, and histopathology of adult zebrafish (Danio rerio). Zebrafish were exposed to virgin or aged polyethylene MPs (0.1% MPs enriched diets, w/w) or waterborne Cd (50 μg/L) or a combination of the two for 21 days. There was an additive interaction between water-borne Cd and MPs on bioaccumulation in males but not in females. Cd accumulation increased by twofold when water-borne Cd and MPs were combined. Water-borne Cd induced significantly higher levels of metallothionein compared to MPs pre-exposed to Cd. However, Cd-treated MPs caused greater damage to the intestine and liver compared to untreated MPs suggesting that bound Cd could be released or modulate MPs toxicity. We also showed that co-exposure to water-borne Cd and MPs increased anxiety in the zebrafish, compared with water-borne Cd alone, suggesting using microplastics as a vector may increase toxicity. This study demonstrates that MPs can enhance the toxicity of Cd, but further study is needed to elucidate the mechanism. © 2023 Elsevier Ltd
引用
收藏
相关论文
共 83 条
[51]  
Pan J., Plant J.A., Voulvoulis N., Oates C.J., Ihlenfeld C., Cadmium levels in Europe: implications for human health, Environ. Geochem. Health, 32, pp. 1-12, (2010)
[52]  
Park, Soo K.J., Jong R.L., Mi J.J., Sang M.P., Sae K.K., Sang C.K., Protective effects of Korean red ginseng extract on cadmium-induced hepatic toxicity in rats, Journal of Ginseng Research, 37, 1, pp. 37-44, (2013)
[53]  
Patel U.N., Patel U.D., Khadayata A.V., Vaja R.K., Patel H.B., Chirag M.M., Assessment of neurotoxicity following Single and Co-Exposure of Cadmium and Mercury in adult zebrafish: behavior alterations, oxidative stress, gene expression, and histological Impairment in brain.” water, air, & Soil Pollution, 232, 8, (2021)
[54]  
Peda C., Letteria C., Maria C.F., Francesco G., Franco A., Lucrezia G., Anna P., Teresa R., Giulia M., Intestinal alterations in European sea bass Dicentrarchus labrax exposed to microplastics: preliminary results, Environ. Pollut., 212, pp. 251-256, (2016)
[55]  
Perez-Escudero A., Julian V., Robert C.H., Sara A., Gonzalo G., IdTracker: tracking individuals in a group by automatic identification of unmarked animals, Nat. Methods, 11, 7, pp. 743-748, (2014)
[56]  
Pi H., Shangcheng X., Russel J.R., Pan G., Lei Z., Yuming L., Li M., Et al., Dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin, Autophagy, 11, 7, pp. 1037-1051, (2015)
[57]  
Rainieri S., Conlledo N., Larsen B.K., Granby K., Barranco A., Combined effects of microplastics and chemical contaminants on the organ toxicity of zebrafish ( Danio rerio), Environ. Res., 162, pp. 135-143, (2018)
[58]  
Renieri, Elisavet A., Dimitris G., Sfakianakis, Athanasios A., Alegakis, Irina V., Safenkova A.B., Vesna M., Maria T., Et al., Nonlinear responses to waterborne cadmium exposure in zebrafish. An in vivo study, Environ. Res., 157, pp. 173-181, (2017)
[59]  
Roesijadi G., Metallothionein and its role in toxic metal regulation, Comp. Biochem. Physiol. C Pharmacol. Toxicol. Endocrinol., 113, 2, pp. 117-123, (1996)
[60]  
Romano N., Munirah A., Jun C.T., Fadhil S., Ali K., Effects of pristine polyvinyl chloride fragments on whole body histology and protease activity in silver barb Barbodes gonionotus fry, Environ. Pollut., 237, pp. 1106-1111, (2018)
123456789