Additive effects of microplastics on accumulation and toxicity of cadmium in male zebrafish

被引：19
作者：
Al Marshoudi M. [1 ,2 ]
Al Reasi H.A. [1 ,3 ]
Al-Habsi A. [1 ]
Barry M.J. [1 ]
机构：
[1] Biology Department, Sultan Qaboos University, PO Box 36, 123, Muscat
[2] Current Address: College of Applied Sciences and Pharmacy, University of Technology and Applied Sciences (UTA), PO Box 74, Al-Khuwair, Muscat
[3] Center for Environmental Studies and Research, Sultan Qaboos University, Al-Khod, PO Box: 17, Muscat
来源：
Chemosphere | 2023年 / 334卷
关键词：
Behavior; Bioaccumulation; Co-exposure; Histopathology; Metallothionein; Vectors;
D O I：
10.1016/j.chemosphere.2023.138969
中图分类号：
学科分类号：
摘要：
Microplastics (MPs) have emerged as contaminants of concern because of their ubiquitous presence in almost all aquatic environments. The ecological effects of MPs are complex and depend on multiple factors including their age, size and the ecological matrix. There is an urgent need for multifactorial studies to elucidate their impacts. We measured the effects of virgin and naturally aged MPs, alone, pretreated with cadmium (Cd), or in combination with ionic Cd, on the bioaccumulation of Cd, metallothionein expression, behavior, and histopathology of adult zebrafish (Danio rerio). Zebrafish were exposed to virgin or aged polyethylene MPs (0.1% MPs enriched diets, w/w) or waterborne Cd (50 μg/L) or a combination of the two for 21 days. There was an additive interaction between water-borne Cd and MPs on bioaccumulation in males but not in females. Cd accumulation increased by twofold when water-borne Cd and MPs were combined. Water-borne Cd induced significantly higher levels of metallothionein compared to MPs pre-exposed to Cd. However, Cd-treated MPs caused greater damage to the intestine and liver compared to untreated MPs suggesting that bound Cd could be released or modulate MPs toxicity. We also showed that co-exposure to water-borne Cd and MPs increased anxiety in the zebrafish, compared with water-borne Cd alone, suggesting using microplastics as a vector may increase toxicity. This study demonstrates that MPs can enhance the toxicity of Cd, but further study is needed to elucidate the mechanism. © 2023 Elsevier Ltd
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共 83 条
[31]  
Huang B., Wei Z.-B., Liu-Yan Y., Pan K., Ai-Jun M., Combined toxicity of silver nanoparticles with hematite or plastic nanoparticles toward two freshwater algae, Environ. Sci. Technol., 53, 7, pp. 3871-3879, (2019)
[32]  
Huggett R.J., Richard A.K., Paul M.M., Harold L.B., Biomarkers: Biochemical, Physiological, and Histological Markers of Anthropogenic Stress, (2018)
[33]  
Ivleva N.P., Alexandra C., Wiesheu, Reinhard N., Microplastic in aquatic ecosystems, Angew. Chem. Int. Ed., 56, 7, pp. 1720-1739, (2017)
[34]  
Jabeen K., Bowen L., Qiqing C., Lei S., Chenxi W., Henner H., Huahong S., Effects of virgin microplastics on goldfish (Carassius auratus), Chemosphere, 213, pp. 323-332, (2018)
[35]  
Kalcikova G., Skalar T., Marolt G., Jemec Kokalj A., An environmental concentration of aged microplastics with adsorbed silver significantly affects aquatic organisms, Water Res., 175, (2020)
[36]  
Kraal M.H., Kraak M.H.S., Degroot C.J., Davids C., Uptake and tissue distribution of dietary and aqueous cadmium by carp (Cyprinus carpio), Ecotoxicol. Environ. Saf., 31, 2, pp. 179-183, (1995)
[37]  
Lacave, Jose M., Eider B., Douglas G., Francesco M., Luciana D., Miren P.C., Amaia O., Bioaccumulation, cellular and molecular effects in adult zebrafish after exposure to cadmium sulphide nanoparticles and to ionic cadmium, Chemosphere, 238, (2020)
[38]  
Li Y., Yue Z., Fei S., Yiyan W., Linlin P., Deze L., Adsorption behaviour of microplastics on the heavy metal Cr(VI) before and after ageing, Chemosphere, 302, (2022)
[39]  
Liu S., Jin H.H., Wei Z., Li Xiu S., Kai X.Y., Han B.Y., Chen Y.Z., Su Z.L., Jiao N.L., Microplastics as a vehicle of heavy metals in aquatic environments: a review of adsorption factors, mechanisms, and biological effects, J. Environ. Manag., 302, (2022)
[40]  
Lu Y., Yan Z., Yongfeng D., Wei J., Yanping Z., Jinju G., Lili D., Hongqiang R., Uptake and accumulation of polystyrene microplastics in zebrafish (Danio rerio) and toxic effects in liver, Environ. Sci. Technol., 50, 7, pp. 4054-4060, (2016)
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