Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue

被引：3
作者：
Jung A. [1 ]
Staat M. [1 ]
机构：
[1] FH Aachen University of Applied Sciences, Faculty of Medical Engineering and Applied Mathematics, Institute of Bioengineering, Jülich
来源：
GAMM Mitteilungen | 2019年 / 42卷 / 04期
关键词：
electromechanical coupling; fibroblasts; hiPSC-derived cardiomyocytes; multi-scale computer model; pharmacology;
D O I：
10.1002/gamm.201900002
中图分类号：
学科分类号：
摘要：
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have become a promising in vitro model for human native cardiomyocytes. Cultivated tissue samples beat autonomously and can be used for basic and pharmacological research. For mechanical measurements of these tissue samples, the CellDrum technology has been developed. Measurements are extended by simulations with a multi-scale electromechanically coupled finite element method based model. This model can be parameterized and validated experimentally. The paper describes the model, its workflow, and preliminary simulations to study the effect of fibroblasts and a selected cardiac drug on the electromechanics of hiPSC-CMs. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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