Non-viral vectors for gene delivery

被引：2
作者：
Bansal A. [1 ]
Himanshu [1 ]
机构：
[1] Department of Chemistry, Hansraj College, University of Delhi, Delhi
来源：
Nanoscience and Nanotechnology - Asia | 2019年 / 9卷 / 01期
关键词：
Electroporation; Gene transfection efficiency; Lipoplexes; Non-viral vectors; Polyplexes; Ultra Sound waves (US waves);
D O I：
10.2174/2210681208666180110154233
中图分类号：
学科分类号：
摘要：
Introduction: Gene therapy has emerged out as a promising therapeutic pave for the treatment of genetic and acquired diseases. Gene transfection into target cells using naked DNA is a simple and safe approach which has been further improved by combining vectors or gene carriers. Both viral and non-viral approaches have achieved a milestone to establish this technique, but non-viral approaches have attained a significant attention because of their favourable properties like less immuno-toxicity and biosafety, easy to produce with versatile surface modifications, etc. Literature is rich in evidences which revealed that undoubtedly, non–viral vectors have acquired a unique place in gene therapy but still there are number of challenges which are to be overcome to increase their effectiveness and prove them ideal gene vectors. Conclusion: To date, tissue specific expression, long lasting gene expression system, enhanced gene transfection efficiency has been achieved with improvement in delivery methods using non-viral vectors. This review mainly summarizes the various physical and chemical methods for gene transfer in vitro and in vivo. © 2019 Bentham Science Publishers.
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页码：4 / 11
页数：7
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