Synthesis and Self-Assembly of Amphiphilic Multi-Block Copolymers

被引：0

作者：

Cheng C. ^{[1
]}

Yang R. ^{[1
]}

Zheng Y. ^{[1
]}

Yang C. ^{[1
]}

Zhou T. ^{[1
]}

Ding M. ^{[1
]}

Tan H. ^{[1
]}

Fu Q. ^{[1
]}

机构：

[1] College of Polymer Science and Engineering of Sichuan University, State Key Laboratory of Polymer Materials Engineering (Sichuan University), Chengdu

来源：

Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering | 2019年 / 35卷 / 10期

关键词：

Drug delivery; Morphology; Multiblock copolymer; Self-assembly;

D O I：

10.16865/j.cnki.1000-7555.2019.0294

中图分类号：

学科分类号：

摘要：

Poly(ethylene glycol)-poly(ε-caprolactone) multi-block copolymers were synthesized, and the hydrophilic-hydrophobic ratios of the copolymers were controlled by molecular design. The structure of the polymers was confirmed by nuclear magnetic resonance spectroscopy (1H-NMR), Fourier transform infrared spectroscopy (FT-IR) and gel permeation chromatography (GPC). The thermal degradation and crystallization properties of the polymers were characterized by thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and X-ray diffraction (XRD). It is noticed that the thermal degradation temperature increases slightly with the increase of hydrophilic blocks in the polymers. Interestingly, the crystallization of the blocks with lower content is inhibited by another type of block. In addition, the particle size and morphology of polymer self-assemblies were characterized by dynamic light scattering (DLS) and transmission electron microscope (TEM). It is found that the self-assemblies change from micelles to vesicles with the increase of hydrophobic block ratios. Furthermore, laser confocal microscopy (CLSM) test and in vitro anti-tumor experiments show that the increase of hydrophilic block contents is beneficial to improving the intracellular release rate and anti-tumor effect of drug carriers. © 2019, Editorial Board of Polymer Materials Science & Engineering. All right reserved.

引用

页码：43 / 48and54

页数：4811

共 13 条

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