Patterned and Biofunctionalized Poly(3, 4-ethylenedioxythiophene) Interfaces

被引：0

作者：

Zhang Y. ^{[1
,2
]}

Lin H.-A. ^{[2
]}

Pan Q. ^{[1
,2
]}

Qian S. ^{[1
,2
]}

Zhang S. ^{[2
]}

Qiu G. ^{[1
]}

Zhu B. ^{[2
]}

机构：

[1] State Key Laboratory for Modification of Chemical Fibers and Polymer Materials & College of Materials Science and Engineering, Donghua University, Shanghai

[2] School of Materials Science and Engineering, Shanghai University, Shanghai

来源：

Cailiao Daobao/Materials Reports | 2021年 / 35卷 / 20期

基金：

中国国家自然科学基金;

关键词：

4-ethylenedioxythiophene); Carboxyl acid; Micropattern; Phosphorylcholine; Poly(3;

D O I：

10.11896/cldb.20080232

中图分类号：

学科分类号：

摘要：

This study demonstrates that functionalized poly(3, 4-ethylenedioxythiophenes) (PEDOTs) with tunable protein/cell interactions and low impedance are applied to fabricate the patterned bio-platform for spatially guiding cell attachment. These functionalized PEDOTs copolymers are prepared by electropolymerized an antifouling EDOT bearing phosphorylcholine (EDOT-PC) and conjugatable EDOT bearing carboxyl acid (EDOT-COOH) into the copolymers. We investigate electrochemical impedance, anti-protein/cell attachment for different composition of the PEDOT copolymers. The specific cell-adhesion on the copolymer surfaces is achieved through grafting RGD peptide on the PEDOTs. Furthermore, we fabricate cell-attachment and cell-repellent micro-patterned PEDOT platforms with different widths by photolithography and electrochemical deposition techniques, the platforms can spatially guide cell attachment effectively, which make it possible for investigating cell behavior. This PEDOT platforms have the potential for tissue repair/regeneration. © 2021, Materials Review Magazine. All right reserved.

引用

页码：20183 / 20189

页数：6

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