Construction of Magnesium Phosphate Chemical Conversion Coatings with Different Microstructures on Titanium to Enhance Osteogenesis and Angiogenesis

被引：7
作者：
Li Y.-B. [1 ,2 ]
Zhang H.-Q. [3 ]
Lu Y.-P. [1 ,2 ]
Yang X.-J. [3 ]
Wang G.-D. [3 ]
Wang Y.-Y. [1 ,2 ]
Tang K.-L. [1 ,2 ]
Huang S.-Y. [3 ,4 ]
Xiao G.-Y. [1 ,2 ]
机构：
[1] Key Laboratory for Liquid−Solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University, Jinan
[2] School of Materials Science and Engineering, Shandong University, Jinan
[3] Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Shandong University, Jinan
[4] Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan
来源：
ACS Applied Materials and Interfaces | 2024年 / 16卷 / 17期
关键词：
angiogenesis; controllable structure; newberyite; osteogenesis; phosphate chemical conversion; titanium;
D O I：
10.1021/acsami.4c03024
中图分类号：
学科分类号：
摘要：
Titanium (Ti) and its alloys are widely used as hard tissue substitutes in dentistry and orthopedics, but their low bioactivity leads to undesirable osseointegration defects in the early osteogenic phase. Surface modification is an important approach to overcome these problems. In the present study, novel magnesium phosphate (MgP) coatings with controllable structures were fabricated on the surface of Ti using the phosphate chemical conversion (PCC) method. The effects of the microstructure on the physicochemical and biological properties of the coatings on Ti were researched. The results indicated that accelerators in PCC solution were important factors affecting the microstructure and properties of the MgP coatings. In addition, the coated Ti exhibited excellent hydrophilicity, high bonding strength, and good corrosion resistance. Moreover, the biological results showed that the MgP coatings could improve the spread, proliferation, and osteogenic differentiation of mouse osteoblast cells (MC3T3-E1) and vascular differentiation of human umbilical vein endothelial cells (HUVECs), indicating that the coated Ti samples had a great effect on promoting osteogenesis and angiogenesis. Overall, this study provided a new research idea for the surface modification of conventional Ti to enhance osteogenesis and angiogenesis in different bone types for potential biomedical applications. © 2024 American Chemical Society.
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页码：21672 / 21688
页数：16
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