Advances in computer simulation of graphene biotoxicity

被引：0
|
作者：
Zhou M. [1 ]
Shen J. [1 ]
Liang L. [2 ]
Li J. [3 ]
Jin L. [1 ]
Wang Q. [3 ]
机构：
[1] School of Medicine, Hangzhou Normal University, Hangzhou, 311121, Zhejiang
[2] School of Artificial Intelligence, Hangzhou Dianzi University, Hangzhou, 310018, Zhejiang
[3] Department of Chemistry, Zhejiang University, Hangzhou, 310027, Zhejiang
来源：
Huagong Xuebao/CIESC Journal | 2020年 / 71卷 / 01期
关键词：
Biomacromolecule; Biomedicine; Biotoxicity; Computer simulation; Graphene;
D O I：
10.11949/0438-1157.20191233
中图分类号：
学科分类号：
摘要：
Graphene is a two-dimensional carbon nanomaterial densely packed into a two-dimensional honeycomb lattice by a flat single-layer carbon atom. Graphene has excellent optical, electrical and mechanical properties and has important application prospects in biomedicine and materials science. With the wide application of graphene in scientific research, its biosafety issues are also received huge attention. Although a large number of studies have shown that graphene has good biocompatibility, some studies have found that graphene has certain biological toxicity. Graphene could interact with proteins, lipids and nucleic acids etc. Because it could permeate through the skin due to its small particle size. Recently, computer simulation has been widely used in the field of biology, chemistry and pharmaceutics etc. due to its low cost, high safety and easy access to dynamic structures which cannot be directly obtained by available experiment technologies. Therefore, in this paper, the computer simulation of the biotoxicity of graphene to cell membrane, proteins and DNA were reviewed, which may provide a reference for graphene biosafety evaluation and biomedical applications. © All Right Reserved.
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页码：148 / 165
页数：17
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