Label-Free Imaging of β-Amyloid Plaques and Photodynamic Degradation

被引：0

作者：

Huang Y. ^{[1
]}

Xu H. ^{[1
]}

Luan P. ^{[2
]}

Ohulchanskyy Tymish Y. ^{[1
]}

Qu J. ^{[1
]}

机构：

[1] Guangdong Province Key Laboratory of Optoelectronic Devices and Systems, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen

[2] Health Science Center, Shenzhen University, Shenzhen

来源：

Zhongguo Jiguang/Chinese Journal of Lasers | 2020年 / 47卷 / 02期

关键词：

Alzheimer's disease; Label-free imaging; Medical optics; Nanoliposomes; Nonlinear optical imaging; Photodynamic therapy;

D O I：

10.3788/CJL202047.0207029

中图分类号：

学科分类号：

摘要：

Formation of β-Amyloid (Aβ) plaques is one of the most significant pathological features of Alzheimer's disease (AD). Detection and degradation of Aβ plaques are crucial in AD treatment. When Aβ monomers aggregate to form plaques, they produce strong autofluorescence. In this study, we investigate label-free imaging of Aβ plaques by using the nonlinear optical imaging method and study their degradation via photodynamic effect of the photosensitizer. Moreover, we study the relationship between photosensitizers with different concentrations and degradation effect of Aβ plaques. Corresponding liposomes are prepared and they are applied to the degradation of Aβ plaques. The potential applications of label-free optical imaging and photodynamic therapy in AD research are discussed, and a new way for optimizing AD diagnosis and treatment is provided. © 2020, Chinese Lasers Press. All right reserved.

引用

共 21 条

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