Application Progress of DVS in the Studies of Drug Polymorphism and Cocrystals

被引：0

作者：

Gong, Lixiang ^{[1
]}

Zhang, Baoxi ^{[1
]}

Tao, Yue ^{[1
]}

Zhou, Jian ^{[1
]}

Yang, Shiying ^{[1
]}

Lyu, Yang ^{[1
]}

机构：

[1] Beijing Key Lab. of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing,100050, China

来源：

Chinese Journal of Pharmaceuticals | 2023年 / 54卷 / 12期

关键词：

Crystals; -; Sorption;

D O I：

10.16522/j.cnki.cjph.2023.12.001

中图分类号：

学科分类号：

摘要：

Dynamic vapor sorption(DVS) technology is served as a crucial tool for the examination of pharmaceutical crystal forms and co-crystals. Not only can DVS technology assess moisture sorption performance of an API, but it also probes into phase transition issues, co-crystal screening, quantification of amorphous content at low levels in crystalline materials, as well as the miscellaneous. At present, many countries and regions have included DVS technology into their pharmacopoeias for the exploration of water-solid interactions. However, the Chinese pharmacopoeia has not recorded this technology. This paper provides an overview of the application and advance of DVS technology in the investigation of pharmaceutical crystal forms and co-crystals, as a reference for related research on polymorphism of drugs. © 2023 Shanghai Institute of Pharmaceutical Industry. All rights reserved.

引用

页码：1687 / 1693