Multimodal Screening - The Future of Drug Discovery and Development

[1] Terry C, Lesser N., Unlocking R&D productivity: Measuring the return from pharmaceutical innovation 2018, (2018)

[2] Santos R, Urso O, Gaulton A, Et al., A comprehensive map of molecular drug targets, Nat. Rev. Drug Discov, 16, pp. 19-34, (2016)

[3] Offord C., RNAi?s future in drug-target screening, The Scientist

[4] Bhinder B, Djaballah H., A decade of RNAi screening: Too much hay and very few needles, Drug Discovery World

[5] Kampmann M, Bassik MC, Weissman JS., Integrated platform for genomewide screening and construction of high-density genetic interaction maps in mammalian cells, Proc. Natl. Acad. Sci. USA, 110, 25, pp. E2317-E2326, (2013)

[6] Morgens DW, Deans RM, Li A, Bassik MC., Systematic comparison of CRISPR/ Cas9 and RNAi screens for essential genes, Nat. Biotechnol, 34, pp. 634-636, (2016)

[7] Shalem O, Sanjana NE, Hartenian E, Et al., Genome-scale CRISPR-Cas9 knockout screening in human cells, Science, 343, pp. 84-87, (2014)

[8] Le Sage C, Lawo S, Panicker P, Et al., Dual direction CRISPR transcriptional regulation screening uncovers gene networks driving drug resistance, Sci. Rep, 7, (2017)

[9] Datlinger P, Rendeiro AF, Schmidl C, Et al., Pooled CRISPR screening with single-cell transcriptome readout, Nat. Methods, 14, pp. 297-301, (2017)

[10] Dixit A, Parnas O, Li B, Et al., Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens, Cell, 167, pp. 1853-1866, (2016)

[1] Terry C, Lesser N., Unlocking R&D productivity: Measuring the return from pharmaceutical innovation 2018, (2018)

[2] Santos R, Urso O, Gaulton A, Et al., A comprehensive map of molecular drug targets, Nat. Rev. Drug Discov, 16, pp. 19-34, (2016)

[3] Offord C., RNAi?s future in drug-target screening, The Scientist

[4] Bhinder B, Djaballah H., A decade of RNAi screening: Too much hay and very few needles, Drug Discovery World

[5] Kampmann M, Bassik MC, Weissman JS., Integrated platform for genomewide screening and construction of high-density genetic interaction maps in mammalian cells, Proc. Natl. Acad. Sci. USA, 110, 25, pp. E2317-E2326, (2013)

[6] Morgens DW, Deans RM, Li A, Bassik MC., Systematic comparison of CRISPR/ Cas9 and RNAi screens for essential genes, Nat. Biotechnol, 34, pp. 634-636, (2016)

[7] Shalem O, Sanjana NE, Hartenian E, Et al., Genome-scale CRISPR-Cas9 knockout screening in human cells, Science, 343, pp. 84-87, (2014)

[8] Le Sage C, Lawo S, Panicker P, Et al., Dual direction CRISPR transcriptional regulation screening uncovers gene networks driving drug resistance, Sci. Rep, 7, (2017)

[9] Datlinger P, Rendeiro AF, Schmidl C, Et al., Pooled CRISPR screening with single-cell transcriptome readout, Nat. Methods, 14, pp. 297-301, (2017)

[10] Dixit A, Parnas O, Li B, Et al., Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens, Cell, 167, pp. 1853-1866, (2016)