The Bottlenecks in Translating Placenta-Derived Amniotic Epithelial and Mesenchymal Stromal Cells Into the Clinic: Current Discrepancies in Marker Reports

被引：0

作者：

Ghamari, Seyyed-Hadi ^{[1
]}

Abbasi-Kangevari, Mohsen ^{[2
]}

Tayebi, Tahereh ^{[1
]}

Bahrami, Soheyl ^{[3
]}

Niknejad, Hassan ^{[1
]}

机构：

[1] Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

[2] Student Research Committee, Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

[3] Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Vienna, Austria

来源：

Frontiers in Bioengineering and Biotechnology | 2020年 / 8卷

关键词：

Cytology; -; Contamination;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Placenta-derived amniotic cells have prominent features for application in regenerative medicine. However, there are still discrepancies in the characterization of human amniotic epithelial and mesenchymal stromal cells. It seems crucial that the characterization of human amniotic membrane cells be investigated to determine whether there are currently discrepancies in their characterization reports. In addition, possible causes for the witnessed discrepancies need to be addressed toward paving the way for further clinical application and safer practices. The objective of this review is to investigate the marker characterization as well as the potential causes of the discrepancies in the previous reports on placenta-derived amniotic epithelial and mesenchymal stromal cells. The current discrepancies could be potentially due to reasons including passage number and epithelial to mesenchymal transition (EMT), cell heterogeneity, isolation protocols and cross-contamination, the region of cell isolation on placental disk, measuring methods, and gestational age. © Copyright © 2020 Ghamari, Abbasi-Kangevari, Tayebi, Bahrami and Niknejad.

引用